Probiotic Goat Milk Powder Fermentation for GABA-Based Sleep Aid
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Solution Overview
Problem
Current sleep-aiding medications for insomnia, such as benzodiazepines, have side effects like resistance and addiction, and there is a need for safer, more effective dietary solutions.
Innovation Solution
A sleep-aiding probiotic goat milk powder is prepared by fermenting goat milk with Limosilactobacillus fermentum KD6, which converts glutamic acid into γ-aminobutyric acid, and is processed via low-temperature spray drying to maintain high probiotic viability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional sleep-aiding medications like benzodiazepines are used, then sleep aid effectiveness is improved, but side effects such as resistance and addiction occur
Solution Approach 1:
The patent uses food-grade probiotics that can be consumed and eliminated naturally through the digestive system, replacing persistent pharmaceutical compounds with biodegradable biological agents that do not accumulate in the body
Solution Approach 2:
The patent introduces probiotics as intermediary organisms that convert glutamic acid to GABA within the digestive system, providing a natural bridge between dietary intake and neurotransmitter production without direct pharmaceutical intervention
2Reliability
If melatonin is used as a sleep-aiding ingredient, then sleep improvement is achieved, but issues such as low body temperature, excessive prolactin release, and reduced male physiological desire occur
Solution Approach 1:
The patent uses food-grade probiotics that are naturally eliminated through digestion, replacing hormonal compounds with biodegradable biological agents that do not cause hormonal imbalances or accumulate in the body
Solution Approach 2:
The probiotics in the fermented goat milk self-regulate by converting glutamic acid to GABA through their metabolic activity, providing sleep aid through natural physiological processes rather than external hormonal intervention
3Stability of the object's composition
If high-temperature processing is used to preserve probiotics, then probiotic stability is improved, but probiotic viability is reduced
Solution Approach 1:
The patent uses spray drying to transition the fermented milk from liquid to powder form through rapid water evaporation, creating a stable dry state that preserves probiotics without requiring high-temperature processing
Solution Approach 2:
The patent changes the temperature parameter during processing, using low-temperature fermentation (30-37°C) followed by spray drying, to maintain probiotic viability while achieving product stability through controlled parameter optimization
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The probiotic goat milk powder is rich in γ-aminobutyric acid, supports sleep aid and intestinal flora balance, and avoids the use of heat-resistant additives, making it safer and more effective than conventional sleep-aiding foods.
Implementation Method 1
Limosilactobacillus fermentum KD6 converts the glutamic acid naturally present in goat milk and the glutamic acid produced from protein decomposition into γ-aminobutyric acid
Implementation Method 2
The fermented goat milk is then processed via low-temperature spray drying to obtain the sleep-aiding probiotic goat milk powder
Data Source
AI summary
A sleep-aiding probiotic goat milk powder and a preparation method thereof are provided. Goat milk is used as the raw material, and the goat milk is sterilized and cooled, then inoculated with Limosilactobacillus fermentum KD6, which produces the sleep-aiding functional factor γ-aminobutyric acid. The strain was deposited in the China Center for Type Culture Collection (CCTCC) on Sep. 7, 2023, with the deposit number CCTCC NO: M20231642. After being stirred evenly, the mixture is fermented at a constant temperature without the need to add precursors of γ-aminobutyric acid such as glutamic acid or sodium glutamate. Upon completion of fermentation, probiotic fermented goat milk containing γ-aminobutyric acid is obtained, and is then subjected to vacuum low-temperature spray drying to obtain the functional sleep-aiding probiotic goat milk powder.