Ultrafine Gold Nanocomposite via CD-MOF Template

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Solution Overview

Problem

Traditional methods for preparing gold nanoparticles result in larger particle sizes with weak antibacterial activity, and often use harmful reagents that limit their application in food and medicine due to residual toxicity.

Innovation Solution

A method for preparing an ultrafine gold nanocomposite by mixing a cyclodextrin metal-organic framework (CD-MOF) material with chloroauric acid and a solvent, followed by incubation, which produces gold nanoparticles with a particle size of 1 nm to 3 nm and retains desirable antibacterial properties without using harmful reagents.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If traditional methods are used to prepare gold nanoparticles, then the preparation process is simple, but the particle size is large (12 nm to 14 nm) and antibacterial activity is weak

Engineering Contradiction:

Improveparticle sizeVSAvoidpreparation process complexity

Core Design Contradiction:

Manufacturing precisionVSEase of manufacture

Solution Approach 1:

The patent uses cyclodextrin metal-organic framework (CD-MOF) as an intermediary template to control gold nanoparticle size. The CD-MOF provides a confined space that limits nanoparticle growth to ultrafine sizes (1-3 nm), solving the particle size control problem without requiring complex multi-step synthesis procedures

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent changes the preparation parameters by using a one-pot incubation method at mild temperatures (25-37°C) with specific molar ratios of γ-CD to chloroauric acid (2.5:1 to 20:1). This parameter optimization enables ultrafine nanoparticle formation while maintaining simple preparation procedures

Inventive Principle:

Principle #35Parameter changes

2Manufacturing precision

If traditional methods are used to reduce particle size, then smaller gold nanoparticles are obtained, but harmful reagents (sodium borohydride and hydrazine hydrate) are required which limit application in food and medicine

Engineering Contradiction:

Improveparticle sizeVSAvoidreagent toxicity

Core Design Contradiction:

Manufacturing precisionVSObject-affected harmful factors

Solution Approach 1:

The patent converts the typically harmful role of reducing agents into a beneficial process by using the mild reducing environment provided by the CD-MOF framework itself. The framework facilitates gold ion reduction to metallic gold nanoparticles without requiring toxic external reducing agents, enabling safe application in food and medicine

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The CD-MOF acts as a safe intermediary that enables nanoparticle formation without direct contact between the final product and harmful reagents. The framework mediates the reduction process using benign components, eliminating toxic residue while maintaining ultrafine particle size

Inventive Principle:

Principle #24Intermediary (Mediator)

3Reliability

If gold nanoparticles with smaller particle sizes are prepared, then higher antibacterial activity is achieved, but harmful reagents remain in the prepared nanoparticles

Engineering Contradiction:

Improveantibacterial activityVSAvoidreagent residue

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent eliminates harmful reagent residues by using a green synthesis approach where the CD-MOF framework provides a benign reducing environment. The process converts potentially harmful chemical reduction into a framework-mediated process that leaves no toxic residues, while maintaining the ultrafine particle size needed for high antibacterial activity

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The patent uses a disposable CD-MOF template that can be easily removed or degraded after nanoparticle formation. The framework serves its purpose during synthesis and can be discarded without concern for residual toxicity, enabling production of ultrafine nanoparticles free from harmful reagent residues

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The ultrafine gold nanocomposite exhibits enhanced antibacterial activity with smaller particle sizes and a broader range of applications, including food, medicine, and environmental fields, while ensuring safety and environmental friendliness.

Implementation Method 1

mixing a cyclodextrin metal-organic framework (CD-MOF) material, chloroauric acid and a solvent to obtain a mixture; and subjecting the mixture to incubation to obtain the ultrafine gold nanocomposite

Methodology Applied

Scientific EffectChemical reduction: Reduction

Data Source

PatentUS20250089721A1Ultrafine gold nanocomposite, and preparation method and use thereof

Publication Date: 2025.03.20 INNOVATION CENTER OF YANGTZE RIVER DELTA ZHEJIANG UNIVERSITY

AI summary

Provided are an ultrafine gold nanocomposite, and a preparation method and use thereof. The preparation method of the ultrafine gold nanocomposite includes the following steps: mixing a cyclodextrin metal-organic framework (CD-MOF) material, chloroauric acid and a solvent to obtain a mixture, and subjecting the mixture to incubation to obtain the ultrafine gold nanocomposite.