Micron-Sized Gold Particles for Local Immune Suppression
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Solution Overview
Problem
Current gold-based treatments for inflammatory diseases and immune disorders face challenges due to adverse effects such as nephrotoxicity and limited localization of gold ions, necessitating a more effective and safer method for delivering gold to affected areas.
Innovation Solution
A kit containing a capped vial with micron-sized gold particles or flakes and a compatible liquid, such as hyaluronic acid, which maintains the gold in suspension for targeted administration, ensuring proper localization and minimizing side effects by using glass beads to facilitate suspension and distribution, thereby allowing direct contact with tissues and controlled release of gold ions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional gold compounds (gold salts) are administered for treatment of inflammatory diseases, then therapeutic benefits are achieved, but nephrotoxicity and adverse effects occur
Solution Approach 1:
The invention divides the gold delivery system into discrete micron-sized particles (20-150 μm) that can be physically separated and localized to specific treatment sites, rather than using dissolved gold salts that circulate systemically. This segmentation allows therapeutic gold to be delivered precisely where needed while avoiding non-target organs like the kidneys.
Solution Approach 2:
The patent implements local quality by enabling direct deposition of gold particles onto implant surfaces and targeted tissue areas. The gold particles are applied locally to the site of inflammation or injury, creating a localized therapeutic effect without systemic circulation, thereby eliminating nephrotoxicity while maintaining therapeutic benefits at the treatment site.
2Reliability
If gold ions are released from gold implants, then immune suppression is achieved, but the release process is not fully controlled
Solution Approach 1:
The invention applies preliminary action by pre-coating implant surfaces with gold particles before insertion into the body. This preliminary placement ensures that gold is already positioned at the treatment site before any biological response occurs, enabling controlled and predictable release kinetics from the outset rather than attempting to control release after implantation.
Solution Approach 2:
The patent uses an intermediary substance (such as hyaluronic acid or other biomaterials) as a carrier matrix for the gold particles. This intermediary provides a controlled release mechanism by regulating the diffusion and degradation rates of the gold particles, thereby controlling the timing and rate of gold ion release while maintaining reliable immune suppression.
3Manufacturing precision
If micron-sized gold particles are used for local application, then localization is improved, but suspension stability becomes challenging
Solution Approach 1:
The invention uses an intermediary carrier substance (such as hyaluronic acid, collagen, or other biocompatible polymers) as a medium to suspend the micron-sized gold particles. This intermediary provides steric hindrance and electrostatic stabilization to prevent particle aggregation and precipitation, while maintaining the particles' micron size for effective localization. The carrier fluid allows the particles to remain stably suspended during administration and at the treatment site.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides a safe and effective, long-lasting immune suppression with reduced side effects, as the gold ions are localized to the treatment site, effectively managing inflammatory diseases and autoimmune conditions without the nephrotoxicity associated with traditional gold compounds.
Implementation Method 1
a liquid, which is capable of maintaining the micron sized gold particles in suspension for at least one minute
Implementation Method 2
at least one glass bead, wherein the liquid is compatible with the human body and is capable of maintaining the micron sized gold particles in suspension
Data Source
AI summary
Sterile micron-sized gold particles contained in capped vials, a kit of part including the vial and a liquid capable of suspending the particles, as well as their preparation, medical devices or medicaments prepared by their preparation as well as uses thereof in treating inflammation. Also, gold coated implants preferably for use in combination with the medical devices.