Gossypol Feed Additive for Ruminant Methane Reduction

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Solution Overview

Problem

Ruminants, particularly cattle, are significant contributors to biogenic methane emissions through enteric fermentation, and existing methods to mitigate methane production from them are not effective enough to stabilize atmospheric methane concentrations.

Innovation Solution

Administering gossypol at a minimum dose of 7.5 g/animal/day, either as a pure compound or in a premix with vitamins and minerals, to reduce methane production from ruminants by inhibiting methanogenic archaea in the rumen fluid.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-generated harmful factors

If feed additives are used to reduce methane production, then methane emission is reduced, but the effectiveness is insufficient to stabilize atmospheric methane concentrations

Engineering Contradiction:
Improvemethane emissionVSAvoideffectiveness of methane reduction
Core Design Contradiction:
Object-generated harmful factorsVSReliability

Solution Approach 1:

The patent changes the chemical parameter by introducing gossypol, a natural phenol compound not previously used for methane reduction. This new chemical substance provides a different mechanism of action against methanogenic archaea, achieving substantially greater methane reduction (at least 30% compared to control) than existing feed additives, thereby resolving the contradiction between reducing methane emission and achieving sufficient effectiveness to stabilize atmospheric concentrations

Inventive Principle:
Principle #35Parameter changes

2Object-generated harmful factors

If gossypol is administered at high doses (at least 7.5 g/animal/day), then methane production is substantially reduced, but the complexity of administration and formulation increases

Engineering Contradiction:
Improvemethane productionVSAvoidadministration and formulation complexity
Core Design Contradiction:
Object-generated harmful factorsVSDevice complexity

Solution Approach 1:

The patent creates a composite feed additive formulation that combines gossypol with carriers and optionally with vitamins and minerals. This composite approach allows the active ingredient (gossypol) to be delivered at effective doses (at least 7.5 g/animal/day) while using the carrier matrix to simplify administration and improve bioavailability, thereby reducing the practical complexity of implementation despite the high dose requirement

Inventive Principle:
Principle #40Composite materials

Solution Approach 2:

The carrier substance acts as an intermediary that facilitates the delivery and absorption of gossypol in the ruminant digestive system. The carrier matrix enables the high dose of gossypol to be administered effectively while improving its bioavailability and reducing the complexity of direct administration, thus resolving the contradiction between achieving substantial methane reduction and maintaining administration simplicity

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Gossypol significantly reduces methane emissions by at least 10% to 30% compared to controls, offering a substantial potential for mitigating climate change by decreasing greenhouse gas emissions from ruminant digestive activities.

Implementation Method 1

gossypol in an amount of at least 7.5 g gossypol/animal/day for reducing the formation of methane emanating from the digestive activities of ruminants

Methodology Applied
Scientific EffectInhibition of methanogenic archaea:

Data Source

PatentUS20240196932A1Novel use
Publication Date: 2024.06.20 DSM IP ASSETS BV
  • US20240196932A1 patent drawing

AI summary

The present invention relates to the field of reduction of methane emission in ruminants. Particularly. it relates to the administration of gossypol in an amount of at least 7.5 g gossypol/animal/day to a ruminant for reducing the production of methane emanating from the diges-5tive activities of said ruminant.