GPR15 Modulators Targeting c10orf99 Interaction
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Solution Overview
Problem
Current treatments for diseases related to the GPR15 ligand/receptor system, such as inflammatory bowel disease, psoriasis, and HIV enteropathy, lack effective modulators to specifically target the interaction between c10orf99 and GPR15, leading to inadequate therapeutic outcomes.
Innovation Solution
Development of modulators, including inhibitors and agonists, that bind to c10orf99 and GPR15 to either inhibit or enhance their interaction, using therapeutic proteins, anti-sense oligonucleotides, or siRNA molecules to regulate the expression and activity of the GPR15 ligand/receptor system.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatments are used for diseases related to the GPR15 ligand/receptor system, then general therapeutic approaches are applied, but specific therapeutic outcomes are inadequate
Solution Approach 1:
The patent introduces modulators (antagonists or agonists) as intermediary substances that specifically bind to the GPR15 receptor or c10orf99 ligand to interfere with or enhance their natural interaction. These modulators serve as mediators between the therapeutic agent and the disease pathway, providing targeted intervention in the GPR15 ligand/receptor system that current non-specific treatments cannot achieve.
2Reliability
If modulators are developed to specifically target the GPR15 interaction, then therapeutic efficacy is enhanced, but treatment complexity increases
Solution Approach 1:
The patent extracts and isolates the specific GPR15 receptor and c10orf99 ligand interaction from the complex disease system, creating targeted modulators that specifically bind to one component (either the receptor or ligand). This extraction approach allows for precise therapeutic intervention at a single molecular target, enhancing efficacy while managing complexity through focused rather than broad-acting mechanisms.
Data Source
AI summary
The present invention relates to modulators of the interaction between G-protein coupled receptor 15(GPR15) and c10orf99. The modulator may be a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described.