Gradient Proportioning Valve With Tight-Tolerance Pressure Pulse Control

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Solution Overview

Problem

Existing gradient proportioning valves (GPVs) in liquid chromatography systems generate undesirable pressure pulses during actuation, leading to compositional errors and reduced accuracy, particularly at higher flow rates, and existing solutions like accumulator diaphragms are costly and limit design freedom.

Innovation Solution

A gradient proportioning valve with a piston and bored structure having tight tolerances to create a fluid-tight seal without deformable seals, using ceramic materials and precise clearances of less than 6 microns to minimize pressure pulses, and actuation mechanisms that rotate or move axially to control fluid flow.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If compliant diaphragms or poppets are used to form seals in GPV, then sealing function is achieved, but pressure pulses are generated causing compositional errors

Engineering Contradiction:
Improvesealing functionVSAvoidpressure pulses
Core Design Contradiction:
ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent removes the compliant sealing elements (diaphragms or poppets) that generate pressure pulses, replacing them with a needle valve mechanism that provides sealing through a needle tip against a seat, eliminating the source of harmful pressure pulses while maintaining sealing function

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent replaces the traditional mechanical sealing system (compliant diaphragms or poppets) with a precision needle valve mechanism where a needle tip creates a fluid-tight seal against a seat, substituting one mechanical sealing approach with another that eliminates pressure pulse generation

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Object-generated harmful factors

If accumulator diaphragms are used upstream of inlet channels to mitigate pressure pulses, then pressure pulse mitigation is improved, but device complexity and cost increase

Engineering Contradiction:
Improvepressure pulsesVSAvoidvalve structure
Core Design Contradiction:
Object-generated harmful factorsVSDevice complexity

Solution Approach 1:

The patent eliminates the need for accumulator diaphragms by integrating pressure pulse mitigation directly into the valve actuation mechanism itself, removing the additional component and simplifying the overall valve structure

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent combines the sealing function and pressure pulse mitigation function into a single integrated needle valve mechanism, where the needle valve both seals the inlet channel and inherently dampens pressure pulses through its design, eliminating the need for separate accumulator components

Inventive Principle:
Principle #5Merging (Combining)

3Object-generated harmful factors

If accumulator chambers are added to mitigate pressure pulses, then pressure pulse mitigation is improved, but manifold space requirements increase

Engineering Contradiction:
Improvepressure pulsesVSAvoidmanifold space
Core Design Contradiction:
Object-generated harmful factorsVSVolume of stationary object

Solution Approach 1:

The patent integrates pressure pulse mitigation functionality directly into the valve body structure through the needle valve mechanism, eliminating the need for separate accumulator chambers and thereby reducing the overall manifold volume requirements

Inventive Principle:
Principle #5Merging (Combining)

4Productivity

If traditional solenoid valves are used to open and close inlet channels, then flow control is achieved, but compositional accuracy decreases due to pressure pulses

Engineering Contradiction:
Improveflow controlVSAvoidcompositional accuracy
Core Design Contradiction:
ProductivityVSMeasurement precision

Solution Approach 1:

The patent replaces the traditional solenoid valve mechanism with a needle valve system that provides superior flow control and compositional accuracy by eliminating pressure pulses through its gradual opening and closing action and inherent damping characteristics

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The valve reduces or eliminates pressure pulses, enhancing compositional accuracy and performance across solvent composition ranges, especially at higher flow rates, without the need for additional sealing elements.

Implementation Method 1

the piston and the bored structure have a tight tolerance configured to create a fluid tight seal when the actuation mechanism closes the at least one of the plurality of conduits

Methodology Applied
Scientific EffectFluid-tight seal through tight tolerances:

Implementation Method 2

a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition

Methodology Applied
Scientific EffectFluid mixing:

Implementation Method 3

an actuation mechanism configured to open and close at least one of the plurality of conduits in a controlled manner

Methodology Applied
Scientific EffectValve actuation: Valve

Implementation Method 4

A gradient proportioning valve with a piston and bored structure having tight tolerances to create a fluid-tight seal without deformable seals, using ceramic materials and precise clearances of less than 6 microns to minimize pressure pulses

Methodology Applied
Scientific EffectPressure pulse dampening: Damping

Data Source

PatentUS12372501B2Gradient proportioning valve
Publication Date: 2025.07.29 WATERS TECHNOLOGY CORP
  • US12372501B2 patent drawing
  • US12372501B2 patent drawing
  • US12372501B2 patent drawing

AI summary

Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, an actuation mechanism having a piston located within a bored structure surrounding the piston, the actuation mechanism configured to open and close at least one of the plurality of conduits in a controlled manner where the piston and the bored structure have a tight tolerance configured to create a fluid tight seal, and a common outlet port configured to receive the fluid composition.