Granular Cannabinoid Composition for Uniform Aqueous Dissolution
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Solution Overview
Problem
Existing cannabinoid solid dosage forms have insufficient systemic absorption and low bioavailability due to non-homogeneous grain size distribution and poor pourability.
Innovation Solution
A method involving convective drying of a matrix liquid containing cannabinoids in a fluidisation apparatus, such as a spouted bed or fluidised bed, to form a stable emulsion with smaller and more homogeneous emulsion particles, enhancing resorbability and bioavailability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional drying methods are used for cannabinoid matrix liquid, then the dosage form can be produced, but the grain size distribution is non-homogeneous and pourability is poor
Solution Approach 1:
The patent applies convective drying in a fluidisation apparatus which changes the drying parameters (heat transfer mode, fluid flow patterns) to achieve homogeneous grain size distribution. This parameter change resolves the contradiction by producing uniform granulates that maintain both manufacturing precision and pourability
Solution Approach 2:
The patent replaces conventional mechanical drying methods with convective drying using fluidisation technology. This substitution creates a more controlled environment that produces homogeneous particles with improved flow properties, simultaneously addressing both manufacturing precision and ease of operation
2Reliability
If conventional solid dosage forms are used, then the product can be manufactured, but systemic absorption is insufficient and bioavailability is low
Solution Approach 1:
The patent changes the physical parameters of the cannabinoid delivery system by using convective drying to create granulates with specific surface area and porosity characteristics. These parameter changes enhance dissolution rate and systemic absorption while maintaining ease of manufacture through a scalable process
Solution Approach 2:
The convective drying process in the fluidisation apparatus creates granulates with controlled porous structure. This porous material characteristic increases surface area for absorption and improves bioavailability while maintaining manufacturability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method results in improved systemic absorption and bioavailability of cannabinoids, with more uniform emulsion particles allowing easy filling and processing into formulations like stickpacks or tablets.
Implementation Method 1
the matrix liquid being convectively dried... into a cannabinoid granulate
Implementation Method 2
the matrix liquid being convectively dried... in a fluidisation apparatus
Implementation Method 3
a first liquid which dissolves a cannabinoid and a second liquid which with the first liquid forms an emulsion
Data Source
AI summary
A process and to an apparatus for production of a granular cannabinoid material essentially soluble in aqueous medium, wherein a matrix liquid composed of a first liquid that dissolves a cannabinoid or composed of a first liquid that dissolves a cannabinoid and a second liquid that forms an emulsion with the first liquid and a cannabinoid dissolved in the first liquid or emulsion is produced. The matrix liquid is dried by convection, and wherein the apparatus has a vessel system having an inlet and a matrix liquid outlet for production of the matrix liquid and a drying apparatus fluidically connected to the matrix liquid outlet of the vessel system.