Grape and Blueberry Extract Mixture for Acute Cognitive Enhancement
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Solution Overview
Problem
Current solutions for improving cognitive performance, such as pharmaceutical stimulants and chronic nutritional supplements, are either unsafe, restrictive, or ineffective when taken in a single dose, and existing acute administration studies with flavonoids have shown mixed and often negative results.
Innovation Solution
A composition comprising a mixture of molecules from Vitis vinifera and Vaccinium angustifolium, specifically with at least 1% catechins and/or epicatechins, 5 ppm ferulic acid, and 200 ppm resveratrol, administered as a single dose to enhance cognitive functions in humans and animals.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If flavonoids are taken chronically for several weeks, then cognitive function is improved, but the solution becomes cumbersome and expensive requiring long-term commitment
Solution Approach 1:
The patent applies preliminary action by formulating a single-dose composition with pre-optimized flavonoid mixtures (including specific ratios of catechins, epicatechins, and other polyphenols) that are prepared in advance to achieve immediate cognitive enhancement without requiring chronic administration. The composition is designed to be taken once before a specific event (e.g., exam), eliminating the need for long-term commitment while maintaining effectiveness.
2Reliability
If high doses of flavonoids are administered in a single dose, then acute cognitive improvement is achieved, but the dose becomes very high and potentially unsafe
Solution Approach 1:
The patent applies parameter changes by optimizing the composition of flavonoid mixtures, specifically adjusting the ratios and types of polyphenols (catechins, epicatechins, and other flavonoids) to achieve acute cognitive enhancement at safe, moderate doses. The composition is formulated with specific concentrations of each component to maximize effectiveness while minimizing risk, avoiding the need for very high single doses.
3Reliability
If existing commercial nutritional solutions are used, then cognitive performance is improved, but they require chronic dosing which is cumbersome and expensive
Solution Approach 1:
The patent applies segmentation by dividing the chronic dosing regimen into a single, optimized dose that contains all necessary flavonoid components in pre-calculated ratios. Instead of requiring continuous supplementation over weeks, the composition is segmented into a one-time administration that delivers the full therapeutic benefit, simplifying the user experience from ongoing commitment to single-use convenience.
4Speed
If flavonoid mixtures are taken in a single dose, then immediate effect is desired, but the activity varies greatly depending on type of flavonoid, dose and age
Solution Approach 1:
The patent applies local quality by tailoring the specific composition of flavonoid mixtures to include particular types and ratios of polyphenols (catechins, epicatechins, and other flavonoids) that are most effective for acute cognitive enhancement. The composition is locally optimized for immediate effect while accounting for variations in flavonoid types, ensuring consistent and reliable cognitive improvement across different users and age groups.
Data Source
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AI summary
The invention concerns the use of a composition comprising at least a mixture of molecules obtained from Vitis vinifera and Vaccinium angustifolium, the mixture comprising: - at least 1% catechins and/or epicatechins, the percentage being given by weight relative to the total weight of the mixture, - at least 5 ppm (parts per million in the mixture) of ferulic acid, and - at least 200 ppm of resveratrol, as a single dose in humans or animals in order to improve or maintain cognitive functions.