Grape Blueberry Polyphenol Mix for Cognitive Bioavailability

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Solution Overview

Problem

Existing berry extracts and grape products have unsatisfactory bioavailability of polyphenols, leading to insufficient effects on cognitive and functional functions in humans and animals.

Innovation Solution

A nutritional or therapeutic agent comprising a molecule mix obtained from Vitis vinifera and Vaccinium angustifolium, containing at least 1% catechin and/or epicatechin, 5 ppm ferulic acid, and optionally 200 ppm resveratrol, 50 ppm quercetin, and 500 ppm anthocyanidins, which enhances the bioavailability and synergistic effects of polyphenols.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing berry extracts and grape products are used, then polyphenols are provided, but bioavailability is unsatisfactory and effect on cognitive functions is insufficient

Engineering Contradiction:

Improvebioavailability of polyphenolsVSAvoideffect on cognitive functions

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The patent combines polyphenols from two different sources - grapes (Vitis vinifera) and blueberries (Vaccinium angustifolium) - into a single composition. This merging of complementary polyphenol profiles from different botanical sources enhances overall bioavailability and cognitive effects compared to using single-source extracts alone

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a composite polyphenolic material by integrating multiple types of polyphenols (flavonoids, anthocyanins, resveratrol, proanthocyanidins) from different plant matrices. This composite approach leverages the synergistic interactions between different polyphenol classes to improve absorption and biological activity

Inventive Principle:

Principle #40Composite materials

2Quantity of substance

If single-source berry extracts are used, then specific polyphenols are provided, but synergistic effects are insufficient

Engineering Contradiction:

Improvepolyphenol concentrationVSAvoidsynergistic effect

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The patent merges polyphenol extracts from grapes and blueberries in specific proportions to achieve synergistic effects. The combination allows for complementary absorption mechanisms and metabolic pathways, enhancing the overall biological activity beyond what single sources can provide

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention optimizes the concentration parameters of different polyphenol types by adjusting the ratio of grape to blueberry extract and controlling extraction conditions. This parameter optimization ensures maximum synergistic interaction between different polyphenol classes while maintaining stable bioavailability

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS12263200B2Specific nutritional or therapeutic agent including a mixture of grape and blueberry

Publication Date: 2025.04.01 ACTIV INSIDE

AI summary

The invention concerns a nutritional or therapeutic agent comprising a molecule mix obtained from Vitis vinifera and Vaccinium angustifolium, comprising:at least 1% of catechins and epicatechins, the percentage being given by weight in relation to the total weight of the mix, preferably at least 5%,at least 5 ppm (parts per million in the mix) of ferulic acid, preferably at least 10 ppm.The invention also relates to the use of this agent due to its effects on cognitive functions in particular.