Grape Seed Extract Modulation of Postprandial Oxidative Stress

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Solution Overview

Problem

Metabolic syndrome patients face challenges with oxidative stress, inflammation, and impaired insulin sensitivity, particularly after consuming high carbohydrate and fat meals, which contribute to insulin resistance and increased cardiovascular risk.

Innovation Solution

Administering a therapeutically effective amount of grape seed extract (GSE) before meals to improve antioxidant status and insulin action, thereby modulating oxidative stress, inflammation, and insulin sensitivity.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Use of energy by moving object

If a high carbohydrate and fat meal is consumed, then energy needs are met, but oxidative stress and inflammation increase

Engineering Contradiction:

Improveenergy from mealVSAvoidoxidative stress

Core Design Contradiction:

Use of energy by moving objectVSObject-affected harmful factors

Solution Approach 1:

Grape seed extract is administered before the meal to preemptively activate antioxidant defenses and reduce the oxidative stress response that would otherwise be triggered by the high carbohydrate and fat meal

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

Grape seed extract acts as an intermediary substance that mediates between the harmful meal components and the body's tissues, reducing oxidative stress and inflammation through its polyphenolic compounds

Inventive Principle:

Principle #24Intermediary (Mediator)

2Object-affected harmful factors

If grape seed extract is administered before meals, then oxidative stress and inflammation are reduced, but the meal's energy provision remains necessary

Engineering Contradiction:

Improveoxidative stress markersVSAvoidpostprandial glucose response

Core Design Contradiction:

Object-affected harmful factorsVSUse of energy by moving object

Solution Approach 1:

The patent changes the temporal parameter of extract administration (before meals) and the dosage parameter (therapeutically effective amount) to achieve oxidation reduction while maintaining appropriate glucose metabolism

Inventive Principle:

Principle #35Parameter changes

3Reliability

If grape seed extract is administered continuously, then antioxidant status improves, but treatment complexity increases

Engineering Contradiction:

Improveantioxidant statusVSAvoidtreatment regimen

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The extract is administered periodically before meals rather than continuously, providing antioxidant benefits while maintaining a manageable treatment schedule that integrates with normal eating patterns

Inventive Principle:

Principle #19Periodic action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Grape seed extract significantly reduces postprandial glucose response and oxidative stress markers, improving insulin efficiency and reducing cardiovascular risk factors in patients with metabolic syndrome.

Implementation Method 1

Grape seeds are a concentrated source of polyphenols and have received considerable attention for their antioxidant capacity and biological effects

Methodology Applied

Scientific EffectAntioxidant: Oxidation

Data Source

PatentUS9592265B2Modulation of oxidative stress, inflammation, and impaired insulin sensitivity with grape seed extract

Publication Date: 2017.03.14 RGT UNIV OF CALIFORNIA

AI summary

Method for modulating oxidative stress, inflammation, and impaired insulin sensitivity in a subject by using a grape seed extract, the method being useful in modulating post-prandial oxidative stress, inflammation, and impaired insulin sensitivity in patients suffering from Metabolic Syndrome (MetS). The method comprising administering a therapeutically effective amount of a grape seed extract and a pharmaceutically acceptable excipient. The grape seed extract is a polyphenolic extract comprising proanthocyanidins and anthocyanidins.