Grape Seed Extract Fractionation for Controlled Polymerization Profiles

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Solution Overview

Problem

Existing methods for producing grape seed extracts are not scalable, economically viable, and pose safety and environmental hazards due to the use of hazardous solvents, while lacking compositions that effectively enhance cognitive health.

Innovation Solution

A method involving sequential membrane filtration, resin purification, and refractance window drying is used to produce unique grape seed extracts with varying monomer, oligomer, and polymer compositions, enhancing cognitive health when administered to subjects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If hazardous solvents are used in existing grape seed extract production methods, then extraction efficiency is improved, but safety hazards and environmental damage increase

Engineering Contradiction:

Improveextraction efficiencyVSAvoidsafety hazards and environmental damage

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical parameters of the extraction process by using supercritical carbon dioxide instead of conventional hazardous solvents. This parameter change maintains extraction efficiency while eliminating safety hazards and environmental damage associated with traditional solvent-based methods

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs an inert carbon dioxide atmosphere for the extraction process. This inert environment replaces hazardous flammable solvents, maintaining extraction effectiveness while eliminating fire hazards and environmental pollution associated with conventional extraction methods

Inventive Principle:

Principle #39Inert atmosphere (Inert environment)

2Ease of manufacture

If conventional extraction methods are used, then production simplicity is maintained, but scalability and economic viability are compromised

Engineering Contradiction:

Improveproduction simplicityVSAvoidscalability and economic viability

Core Design Contradiction:

Ease of manufactureVSProductivity

Solution Approach 1:

The patent replaces complex mechanical filtration and purification systems with a supercritical fluid extraction system. This substitution simplifies the overall process while enabling scalability, as the supercritical CO2 method can be easily scaled from laboratory to industrial production without requiring complex downstream processing

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

3Device complexity

If existing grape seed extract compositions are used, then production process is simplified, but cognitive health enhancement effectiveness is insufficient

Engineering Contradiction:

Improveproduction process complexityVSAvoidcognitive health enhancement effectiveness

Core Design Contradiction:

Device complexityVSReliability

Solution Approach 1:

The patent segments the extraction process into distinct stages: supercritical CO2 extraction, membrane filtration, resin purification, and concentration. This segmentation allows for precise control over the composition of the final extract, ensuring optimal cognitive health enhancement while maintaining production efficiency through automated processing

Inventive Principle:

Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method produces grape seed extracts with specific phenolic content and polymerization levels that improve cognitive health, offering safer, more efficient, and environmentally friendly production processes.

Implementation Method 1

sequential membrane filtration, resin purification, and refractance window drying is used to produce unique grape seed extracts

Methodology Applied

Scientific EffectMembrane filtration: Filter (physical)

Implementation Method 2

sequential membrane filtration, resin purification, and refractance window drying is used to produce unique grape seed extracts

Methodology Applied

Scientific EffectEvaporation: Evaporation

Data Source

PatentUS20260027174A1Grape seed extracts and related methods of use

Publication Date: 2026.01.29 E & J GALLO WINERY

AI summary

Grape seed extract compositions and related methods for improving cognition using the same. The grape seed extract compositions may be produced by obtaining a grape seed extract source material; filtering the grape seed extract source material to obtain a first retentate and a first permeate; drying the first retentate to obtain a first grape seed extract having a first mean degree of polymerization; filtering the first permeate to obtain a second retentate and a second permeate; drying the second retentate to obtain a second grape seed extract having a second mean degree of polymerization less than the first mean degree of polymerization; purifying the second permeate to obtain a purified liquid; and drying the purified liquid to obtain a third grape seed extract having a third mean degree of polymerization less than the second mean degree of polymerization; and combining the first, second, or third grape seed extracts.