Grapevine Stem Extract Composition for HSV-1 and Amyloid Control
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Solution Overview
Problem
Current therapeutic agents for Alzheimer's disease, particularly those targeting Aβ aggregation, have shown no special therapeutic effect, and there is a lack of compositions using grapevine stem extract or compounds isolated therefrom for preventing or treating Alzheimer's disease.
Innovation Solution
A composition comprising grapevine stem extract or vitisin A is developed to inhibit herpes simplex virus infection and reduce the production of amyloid beta and phosphorylation of tau protein, which are Alzheimer-causing factors.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current therapeutic agents targeting Aβ aggregation are used, then the goal of controlling abnormal protein accumulation is addressed, but no special therapeutic effect is achieved
Solution Approach 1:
The grapevine stem extract is demonstrated to perform multiple functions: inhibiting Aβ aggregation, suppressing HSV-1 infection, and reducing neuroinflammation. This multi-functional approach addresses multiple pathological mechanisms of Alzheimer's disease simultaneously, explaining why it shows therapeutic effects where single-target agents have failed
2Reliability
If grapevine stem extract is used to inhibit HSV-1 infection and reduce amyloid beta production, then Alzheimer's disease treatment effectiveness is improved, but the complexity of the composition increases
Solution Approach 1:
The invention extracts and isolates specific bioactive compounds (vitisin A, vitisin B, ε-viniferin) from grapevine stem extract. This extraction process simplifies the composition by identifying and utilizing only the most effective components, reducing complexity while maintaining or enhancing therapeutic effectiveness
Solution Approach 2:
The invention utilizes a composite of multiple bioactive compounds naturally present in grapevine stem extract. These compounds work synergistically to address multiple pathological aspects of Alzheimer's disease, achieving complex therapeutic effects through a naturally occurring composite rather than synthetic combinations
3Adaptability or versatility
If grapevine stem extract is utilized for Alzheimer's disease treatment, then new therapeutic options are provided, but research on grapevine stem functionality remains insufficient
Solution Approach 1:
The invention performs preliminary research and characterization of grapevine stem extract components before clinical application. By identifying and isolating specific bioactive compounds (vitisin A, vitisin B, ε-viniferin) and characterizing their mechanisms of action, the invention builds a knowledge foundation that enables future therapeutic development while reducing information gaps
Data Source
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AI summary
The present invention relates to a composition for preventing, ameliorating, or treating Alzheimer's disease comprising grapevine stem extract or a compound isolated therefrom as an effective component. Specifically, as the grapevine stem extract and vitisin A as an effective component of the present invention exhibit an excellent effect of inhibiting infection with the herpes simplex virus and inhibiting Alzheimer-causing factors in the brain tissue of animal models infected with the herpes simplex virus, the composition of the present invention can be advantageously used as an agent for treating Alzheimer's disease or a functional health food or an animal feed additive for preventing or ameliorating Alzheimer's disease.