Graph Embedding for Biological Dataset Classification

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Solution Overview

Problem

Current medical decision support systems struggle to accurately classify cancer stages and detect new classes within datasets, particularly in late-stage cancer diagnosis and treatment, where conventional methods fail to provide efficient and effective treatment due to high-dimensional data complexity and human error in training sets.

Innovation Solution

The use of Graph Embedding to reduce dimensionality in biological datasets, allowing for supervised or unsupervised classification by assigning features to an embedded space based on posterior likelihood, partitioning features into disjoint regions, and generating new distributions for identifying new classes, thereby improving classification accuracy and detecting novel classes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional classification methods are used on high-dimensional biological datasets, then the system can process the data, but the classification accuracy deteriorates due to high-dimensional data complexity

Engineering Contradiction:
Improveclassification accuracyVSAvoiddata dimensionality
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent applies Graph Embedding to transform high-dimensional biological data into a lower-dimensional embedded space while preserving the intrinsic manifold structure. This dimensionality reduction technique maps data points from high-dimensional space to a lower-dimensional space, reducing complexity while maintaining classification accuracy by preserving the essential relationships and patterns in the data.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

2Adaptability or versatility

If conventional classification methods are used, then the system can operate, but the ability to detect new classes deteriorates due to reliance on pre-defined classes

Engineering Contradiction:
Improvenew class detection capabilityVSAvoidclassification system rigidity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent employs unsupervised learning algorithms that dynamically adapt to the data structure without relying on pre-defined class labels. The system automatically discovers and identifies new classes by analyzing the intrinsic patterns and relationships in the data, making the classification system flexible and adaptable to previously unknown categories while maintaining operational efficiency.

Inventive Principle:
Principle #15Dynamics

3Reliability

If human experts manually classify data, then the system can identify patterns, but the reliability deteriorates due to human error in training sets

Engineering Contradiction:
Improveclassification consistencyVSAvoidmanual intervention level
Core Design Contradiction:
ReliabilityVSExtent of automation

Solution Approach 1:

The patent implements automated machine learning algorithms that self-train and self-validate without requiring manual expert intervention. The system automatically processes biological data, applies Graph Embedding for dimensionality reduction, and performs classification using supervised or unsupervised learning algorithms, thereby eliminating human errors in training set creation and improving classification consistency and reliability.

Inventive Principle:
Principle #25Self-service

Data Source

PatentUS8204315B2Systems and methods for classification of biological datasets
Publication Date: 2012.06.19 THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
  • US8204315B2 patent drawing
  • US8204315B2 patent drawing
  • US8204315B2 patent drawing

AI summary

This invention relates to supervised or unsupervised classification of biological datasets. Specifically, the invention relates to the use of Graph Embedding as a method of reducing dimensionality thereby improving supervised classification of classes, both conventional and new ones.