Graphene Oxide Membrane for Dialysate Regeneration

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Solution Overview

Problem

Current sorbent systems for reconstituting spent dialysate are bulky and require replacement after each use, necessitating an improved method for regenerating dialysate in dialysis therapy.

Innovation Solution

A graphene oxide-based membrane with functionalized single-layered graphene oxide layers and a porous conductive substrate is developed, allowing for the selective removal of excess ions from spent dialysate through an electrocapacitive unit, enabling regeneration without the need for enrichment solutions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Loss of substance

If sorbent cartridges are used to remove waste from spent dialysate, then waste removal is achieved, but the system occupies considerable space and requires replacement after each use

Engineering Contradiction:
Improvewaste removal efficiencyVSAvoidsorbent cartridge volume
Core Design Contradiction:
Loss of substanceVSVolume of moving object

Solution Approach 1:

The invention changes the physical and chemical parameters of the membrane by functionalizing graphene oxide layers with diamine groups and controlling interlayer spacing to ≤10 Å, enabling the membrane to selectively remove waste molecules while maintaining a compact structure that doesn't require frequent replacement

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The invention uses composite material structure combining multiple layers of functionalized single-layered graphene oxide on a porous substrate, creating a material that integrates both filtration and structural support functions, eliminating the need for bulky sorbent cartridges

Inventive Principle:
Principle #40Composite materials

2Reliability

If sorbent cartridges are used for waste removal, then dialysate regeneration is achieved, but the cartridges must be replaced after each use maintaining high regeneration efficiency

Engineering Contradiction:
Improveregeneration efficiencyVSAvoidsorbent cartridge lifespan
Core Design Contradiction:
ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The functionalized graphene oxide membrane enables the system to automatically regenerate dialysate through selective waste removal and ion exchange mechanisms, with the durable membrane structure allowing repeated use without replacement, making the system self-sustaining over multiple cycles

Inventive Principle:
Principle #25Self-service

3Productivity

If conventional sorbent systems are used, then spent dialysate can be reconstituted, but the system complexity and space requirements increase

Engineering Contradiction:
Improvedialysate reconstitution capabilityVSAvoidsorbent system complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The invention extracts the essential function of waste removal from complex sorbent cartridges and implements it through a thin-film membrane structure, eliminating unnecessary bulk and complexity while retaining the core dialysate regeneration capability

Inventive Principle:
Principle #2Taking out (Extraction)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The membrane effectively removes excess ions from spent dialysate, allowing for repeated use of the regenerated dialysate without the need for sorbent replacement, reducing waste and improving dialysis efficiency.

Implementation Method 1

each of the plurality of layers of single-layered graphene oxide is functionalised by at least one diamine functional group

Methodology Applied
Scientific EffectIon exchange: Ion Exchange

Implementation Method 2

functionalised by at least one diamine functional group... selective removal of excess ions

Methodology Applied
Scientific EffectElectrostatic interaction: Electrostatics

Implementation Method 3

The substrate may be a porous conductive substrate... the porous conductive substrate may be a porous carbon-based conductive substrate

Methodology Applied
Scientific EffectElectrical conduction: Conduction (electrical)

Implementation Method 4

heating the nascent membrane to form the graphene oxide-based membrane

Methodology Applied
Scientific EffectEvaporation: Evaporation

Data Source

PatentUS20230201776A1A graphene oxide-based membrane
Publication Date: 2023.06.29 SINGAPORE HEALTH SERVICES PTE LTD
  • US20230201776A1 patent drawing
  • US20230201776A1 patent drawing
  • US20230201776A1 patent drawing

AI summary

A graphene oxide-based membrane There is provided a graphene oxide-based membrane comprising a substrate and a plurality of layers of single-layered graphene oxide formed on the substrate, each of the plurality of layers of single-layered graphene oxide is functionalised by at least one diamine functional group, wherein interlayer spacing between two adjacent layers of single-layered graphene oxide is ≤ 10 Å. The membrane may be comprised in an electrocapacitive unit. There is also provided a method of forming the membrane.