Green Coffee and Rosemary Extract Composition for Atherosclerosis Treatment
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Solution Overview
Problem
Current treatments for cardiovascular diseases, particularly those resulting from atherosclerosis, often rely on synthetic ingredients that can have negative health effects, prompting a need for natural alternatives that can effectively reduce atherosclerotic plaque formation, lower oxidized LDL levels, and increase HDL levels.
Innovation Solution
A composition combining green coffee extract and Lamiaceae extract, such as rosemary extract, which is formulated to reduce atherosclerotic plaque formation, decrease LDL levels, and decrease 8-iso-PGF2α levels, utilizing specific weight percentages of chlorogenic acid, carnosic acid, and carnosol, and can be administered in various forms including pharmaceutical, nutraceutical, and food products.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If synthetic ingredients are used to treat cardiovascular diseases, then treatment effectiveness is improved, but negative health effects increase
Solution Approach 1:
The patent changes the chemical composition parameters by using natural plant extracts (green coffee extract containing chlorogenic acid and Lamiaceae extract containing carnosic acid and carnosol) instead of synthetic ingredients, thereby maintaining treatment effectiveness while eliminating negative health effects associated with synthetic compounds
Solution Approach 2:
The patent combines multiple natural plant extracts (green coffee extract and Lamiaceae extract) to create a composite natural composition that works synergistically to treat cardiovascular diseases, achieving the therapeutic effects previously obtained from synthetic ingredients without their harmful side effects
2Object-generated harmful factors
If natural alternatives are used to replace synthetic ingredients, then health safety is improved, but treatment effectiveness may worsen
Solution Approach 1:
The patent merges multiple natural plant extracts (green coffee extract with chlorogenic acid and Lamiaceae extract with carnosic acid and carnosol) into a single composition, creating a synergistic effect that achieves treatment effectiveness comparable to or exceeding synthetic ingredients while maintaining health safety
Solution Approach 2:
The patent optimizes the concentration parameters of active compounds (chlorogenic acid, carnosic acid, carnosol) in the natural extract composition to ensure sufficient treatment effectiveness while maintaining the health safety benefits of natural ingredients
3Reliability
If green coffee extract and Lamiaceae extract are combined, then antioxidant effect is improved, but formulation complexity increases
Solution Approach 1:
The patent combines green coffee extract and Lamiaceae extract into a single integrated composition, allowing the synergistic antioxidant effects of chlorogenic acid, carnosic acid, and carnosol to work together while managing formulation complexity through unified development
Data Source
AI summary
The present invention relates to compositions comprising a green coffee extract and a Lamiaceae extract (such as a rosemary extract), the use of these composition in treating cardiovascular conditions, in particular, cardiovascular conditions resulting from atherosclerosis and methods of making the compositions.