Green Tea Extract Composition for Cognitive Function Enhancement

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Solution Overview

Problem

Current treatments for cognitive decline and neurodegenerative diseases, such as Alzheimer's, are ineffective and have significant side effects, necessitating a natural therapeutic agent that enhances cognitive function without toxicity.

Innovation Solution

A composition comprising 5 to 25% (−)-gallocatechin gallate (GCG) and 7 to 15% (−)-epigallocatechin gallate (EGCG) from green tea extract, administered through a method involving ethanol extraction and concentration, is used to ameliorate cognitive decline and treat neurodegenerative diseases.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If conventional acetylcholinesterase inhibitor drugs are used to treat Alzheimer's dementia, then acetylcholine concentration in the brain is increased, but the therapeutic effect is limited and side effects occur

Engineering Contradiction:

Improveacetylcholine concentrationVSAvoidtherapeutic effectiveness

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The patent changes the chemical parameters by using green tea extract containing specific ratios of GCG (5-25%) and EGCG (7-15%) instead of conventional acetylcholinesterase inhibitors. This natural extract modifies the biochemical parameters in the brain to enhance cognitive function without the limitations of synthetic drugs, thereby improving therapeutic effectiveness while maintaining safe acetylcholine levels.

Inventive Principle:

Principle #35Parameter changes

2Object-affected harmful factors

If natural materials are used as therapeutic agents, then toxicity is reduced, but the therapeutic effect is unclear

Engineering Contradiction:

ImprovetoxicityVSAvoidtherapeutic effect

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent uses a composite natural extract from green tea containing multiple active compounds (GCG and EGCG) in specific ratios. This composite material combines the benefits of natural safety with enhanced therapeutic effectiveness through the synergistic action of multiple compounds, resolving the contradiction between low toxicity and clear therapeutic effect.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent optimizes the concentration parameters of GCG (5-25%) and EGCG (7-15%) in the green tea extract to achieve maximum therapeutic effect. By precisely controlling these compositional parameters, the patent ensures both safety and effectiveness, making the therapeutic effect clear and reliable while maintaining low toxicity.

Inventive Principle:

Principle #35Parameter changes

3Reliability

If green tea extract with conventional composition is used, then cognitive function enhancement is observed, but the specific active ingredients and their optimal ratios are not identified

Engineering Contradiction:

Improvecognitive function enhancementVSAvoidingredient composition control

Core Design Contradiction:

ReliabilityVSManufacturing precision

Solution Approach 1:

The patent precisely defines the compositional parameters of GCG (5-25%) and EGCG (7-15%) in the green tea extract. By establishing these specific concentration ranges, the patent enables controlled manufacturing with consistent quality, ensuring reliable cognitive function enhancement while solving the problem of undefined ingredient ratios in conventional green tea extracts.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The green tea extract composition effectively enhances acetylcholine metabolism, inhibits DNA methylation, reduces lipid peroxidation, and improves cognitive function, thereby ameliorating cognitive decline and treating neurodegenerative diseases without toxicity, improving the quality of life for patients.

Implementation Method 1

The green tea extract composition effectively enhances acetylcholine metabolism

Methodology Applied

Scientific EffectAcetylcholine metabolism enhancement:

Implementation Method 2

inhibits DNA methylation

Methodology Applied

Scientific EffectDNA methylation inhibition:

Implementation Method 3

reduces lipid peroxidation

Methodology Applied

Scientific EffectLipid peroxidation reduction: Oxidation

Data Source

PatentUS10799551B2Composition for enhancing cognitive function comprising green tea extract which has modified amounts of ingredients

Publication Date: 2020.10.13 AMOREPACIFIC CORP

AI summary

Disclosed is to provide a composition derived from a natural material and which has an excellent effect of enhancing cognitive function and a method for preparing the same. The extract and composition according to one aspect of the present disclosure are derived from a natural material and thus are safe. It can prevent, ameliorate and treat cognitive decline. Therefore, it allows to improve the quality of life of the elderly population without concerns about side effects and promote development of the related industry.