Green Tea Peptide Composition for Anti-Obesity via Lipid Metabolism
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Solution Overview
Problem
Current anti-obesity drugs have serious side effects and there is a need for effective and safer substances that can inhibit fat cell differentiation and promote lipid metabolism, particularly from natural sources.
Innovation Solution
A composition containing a green tea peptide, isolated and purified by culturing green tea protein with a specific plant-based lactic acid bacterium, which inhibits lipid synthesis, promotes fat oxidation, and enhances mitochondrial biosynthesis, thereby addressing obesity effectively.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing anti-obesity drugs (orlistat, sibutramine) are used, then anti-obesity effect is achieved, but serious side effects occur (vomiting, constipation, gastrointestinal disorders, cardiovascular disease)
Solution Approach 1:
The patent replaces conventional synthetic anti-obesity drugs with a natural peptide composition derived from green tea and lactic acid bacteria. This natural alternative is intended to be safer and more sustainable, avoiding the serious side effects of existing drugs while maintaining anti-obesity efficacy through inhibition of fat cell differentiation and promotion of lipid metabolism.
Solution Approach 2:
The patent modifies the chemical composition parameters by using a peptide fraction with specific molecular weight range (1-10 kDa) derived from green tea protein through lactic acid bacteria fermentation. This parameter optimization enables the peptide to inhibit lipid synthesis and promote fat oxidation without the harmful side effects of conventional drugs.
2Object-affected harmful factors
If natural sources are used to develop anti-obesity substances, then safety is improved, but effectiveness and potency may be reduced
Solution Approach 1:
The patent creates a composite peptide composition by fermenting green tea protein with lactic acid bacteria, resulting in a synergistic mixture that enhances anti-obesity effects. The composite nature of this natural peptide fraction allows it to simultaneously inhibit lipid synthesis, promote fat oxidation, and enhance mitochondrial biosynthesis, achieving drug-like effectiveness while maintaining safety.
Solution Approach 2:
The patent optimizes the molecular weight parameter of the peptide fraction (1-10 kDa) to enhance its biological activity. This parameter optimization ensures that the natural peptide composition achieves sufficient potency to effectively inhibit fat cell differentiation and promote lipid metabolism, bridging the gap between safety and effectiveness.
3Weight of moving object
If conventional anti-obesity approaches are used, then weight loss is achieved, but lipid metabolism abnormalities persist (increase in triglycerides, LDL-cholesterol, decrease in HDL-cholesterol)
Solution Approach 1:
The patent employs a natural peptide composition that continuously promotes healthy lipid metabolism rather than merely suppressing weight loss. The peptide fraction continuously inhibits lipid synthesis, promotes fat oxidation, and enhances mitochondrial biosynthesis, ensuring sustained improvement in lipid metabolism parameters (triglycerides, LDL-cholesterol, HDL-cholesterol) alongside weight management.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The green tea peptide composition demonstrates significant anti-obesity effects by reducing fat accumulation, improving lipid metabolism, and increasing mitochondrial activity, offering a safer and more effective alternative to existing drugs.
Implementation Method 1
isolated and purified by culturing a green tea protein and a specific plant-based lactic acid bacterium
Implementation Method 2
The green tea peptide composition may be obtained by fermenting a green tea protein with a plant-based lactic acid bacterium
Data Source
AI summary
The present disclosure relates to a composition for anti-obesity including a green tea peptide composition. Specifically, the green tea peptide composition according to the one aspect of the present disclosure exhibits anti-obesity efficacy through excellent lipid metabolism activation and can be applied to various health functional food compositions and pharmaceutical compositions.