Anhydrous Guanine Co-Crystals With Controlled Morphology and Refraction

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Solution Overview

Problem

The industrial use of synthetic anhydrous guanine crystals is hindered by their insolubility in most solvents and the difficulty in obtaining crystals with the desired morphology and thickness for high refractive index, leading to poor quality and high costs in extraction and purification.

Innovation Solution

A pH and temperature controlled process is employed to prepare synthetic co-crystals of anhydrous guanine with additional materials, involving the preparation of basic or acidic aqueous solutions, filtration, pH adjustment, and crystallization to achieve controlled crystal morphology and refractive index.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If synthetic anhydrous guanine is prepared using conventional methods, then the production process is simplified, but the crystal morphology and thickness cannot be controlled to achieve the desired high refractive index

Engineering Contradiction:
Improveproduction process simplicityVSAvoidcrystal morphology control
Core Design Contradiction:
Ease of manufactureVSManufacturing precision

Solution Approach 1:

The patent applies parameter changes by controlling pH levels and temperature conditions during the crystallization process to achieve desired crystal morphology and thickness while maintaining manufacturing simplicity

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent uses co-crystallization with additional materials to form composite crystal structures that achieve the desired morphology and refractive index properties without complicating the overall production process

Inventive Principle:
Principle #40Composite materials

2Shape

If natural guanine crystals are extracted from fish scales, then the desired crystal morphology is obtained, but the extraction and purification process becomes complex and costly

Engineering Contradiction:
Improvecrystal morphologyVSAvoidextraction and purification process
Core Design Contradiction:
ShapeVSDevice complexity

Solution Approach 1:

The patent extracts only the essential crystallization properties from natural guanine by using synthetic co-crystallization methods, eliminating the need for complex extraction and purification of fish scale materials while maintaining desired crystal morphology

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent creates synthetic copies of natural guanine crystal structures through controlled co-crystallization processes, replicating the desired morphology without requiring actual natural material extraction

Inventive Principle:
Principle #26Copying

3Ease of manufacture

If synthetic anhydrous guanine is prepared without co-crystallization, then the production process is simpler, but the refractive index and optical quality are insufficient

Engineering Contradiction:
Improveproduction process simplicityVSAvoidrefractive index quality
Core Design Contradiction:
Ease of manufactureVSReliability

Solution Approach 1:

The patent employs co-crystallization with additional materials to create composite crystal structures that achieve the required refractive index between 1.65-1.95 while maintaining relatively simple production processes

Inventive Principle:
Principle #40Composite materials

Solution Approach 2:

The patent optimizes crystallization parameters including pH and temperature to control the formation of co-crystals with specific optical properties, ensuring high refractive index quality without significantly complicating manufacturing

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The process enables the production of synthetic co-crystals with a refractive index between 1.65-1.95, providing high pearlescence and whiteness, suitable for applications in paints, coatings, and cosmetics.

Implementation Method 1

adjusting the pH of the filtrate by adding a base or an acid to the filtrate over a predefined period of time until a predetermined pH value is obtained

Methodology Applied
Scientific EffectpH adjustment:

Implementation Method 2

a pH and temperature controlled process is employed to prepare synthetic co-crystals of anhydrous guanine with additional materials, involving the preparation of basic or acidic aqueous solutions, filtration, pH adjustment, and crystallization

Methodology Applied
Scientific EffectCrystallization: Crystallisation

Implementation Method 3

A pH and temperature controlled process is employed to prepare synthetic co-crystals of anhydrous guanine with additional materials

Methodology Applied
Scientific EffectTemperature control:

Implementation Method 4

Some of the most brilliant colors in nature are produced by the interaction of light with structured materials, causing light scattering or reflection

Methodology Applied
Scientific EffectLight scattering: Scattering

Implementation Method 5

Some of the most brilliant colors in nature are produced by the interaction of light with structured materials, causing light scattering or reflection

Methodology Applied
Scientific EffectLight reflection: Reflection

Implementation Method 6

the co-crystals have a high refraction index and therefore, provide products with pearlescence or whiteness with high coverage

Methodology Applied
Scientific EffectRefraction: Refraction

Data Source

PatentUS12473287B2Synthetic co-crystals of anhydrous guanine and process for preparing the same
Publication Date: 2025.11.18 ECOCRYSTAL LTD
  • US12473287B2 patent drawing
  • US12473287B2 patent drawing
  • US12473287B2 patent drawing

AI summary

This invention is directed to synthetic co-crystals of anhydrous guanine and at least one additional material, wherein the co-crystals have a high refraction index and therefore, provide products with pearlescence or whiteness with high coverage. The invention is further directed to a process for the preparation of anhydrous guanine and of the co-crystals.