Guava Leaf Extract Elevates Adiponectin Levels
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Solution Overview
Problem
There is a lack of safe and effective substances that can elevate blood adiponectin levels over a long period, with only fermented tea extract reported to have this effect, and guava leaf extract has not been previously associated with this benefit.
Innovation Solution
Guava leaf extract, obtained through water or hydrophilic solvent extraction from guava leaves, is used as an active ingredient to elevate blood adiponectin levels, offering a safe and effective solution for treating or preventing hypoadiponectinemia.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If fermented tea extract is used to elevate blood adiponectin level, then the effect of elevating adiponectin is achieved, but the variety of available substances is limited and safety for long-term use is not well-established
Solution Approach 1:
The patent changes the chemical composition parameter by introducing guava leaf extract, which contains different active compounds (such as flavonoids and tannins) compared to fermented tea extract. This parameter change provides a new substance option that maintains the adiponectin-elevating effect while offering different safety and efficacy characteristics for long-term use
2Reliability
If guava leaf extract is used for health-maintenance beverages, then safety and long-term consumability are achieved, but the effect of elevating blood adiponectin level has not been previously demonstrated
Solution Approach 1:
The patent establishes a feedback loop by measuring blood adiponectin levels before and after administration of guava leaf extract. The experimental results provide feedback confirmation that guava leaf extract effectively elevates adiponectin levels, thereby validating both the safety (from historical use) and the therapeutic effect (from new evidence) simultaneously
3Quantity of substance
If a substance is to be used for treating hypoadiponectinemia, then therapeutic effect is achieved, but the substance must be safe enough for long-term daily intake
Solution Approach 1:
The patent converts the historical limitation (lack of known therapeutic effect) into a benefit by discovering that guava leaf extract, already established as safe for long-term consumption in health beverages, unexpectedly elevates adiponectin levels. This transforms a substance known only for safety into one with proven therapeutic value, eliminating the trade-off between efficacy and safety
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Guava leaf extract effectively elevates adiponectin levels with minimal side effects, making it suitable for long-term use in treating or preventing diseases associated with hypoadiponectinemia, such as diabetes and arteriosclerosis, and demonstrates safety through its historical use in health-maintenance beverages.
Implementation Method 1
the guava leaf extract is obtained from guava leaves through extraction with water and/or a hydrophilic solvent
Data Source
AI summary
To provide a highly safe medicament or food or beverage which exhibits the effect of elevating blood adiponectin level, and which allows intake thereof over a long period of time. The invention provides an adiponectin level elevating agent including guava leaf extract as an active ingredient.