Gut Microbiota Composition for DNase Modulation and Barrier Integrity
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Solution Overview
Problem
Current compositions fail to effectively modulate deoxyribonuclease activity, leading to issues such as intestinal barrier dysfunction, neurodegenerative diseases, and various chronic conditions like diabetes and cancer, due to the formation of bacterial amyloid and DNA-protein complexes in the gut microbiota.
Innovation Solution
Compositions comprising magnesium and sodium cations, along with additives like ascorbic acid and plant extracts, are used to modulate DNase activity, preventing DNA-protein complex formation and maintaining gut barrier function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current compositions are used, then DNase activity modulation is insufficient, but intestinal barrier dysfunction and disease risk increase
Solution Approach 1:
The patent changes the chemical parameters of the composition by specifying precise concentrations of magnesium cations (6.0-155.0 mg/l) and sodium cations (0.005-12.0 mg/l), along with controlled pH levels (6.0-7.5), to optimize DNase activity modulation and prevent pathological conditions
Solution Approach 2:
The patent creates a composite water composition containing multiple components working synergistically: magnesium cations, sodium cations, and water, with optional additives like ascorbic acid and plant extracts, to achieve enhanced DNase modulation and gut barrier protection
2Stability of the object's composition
If bacterial amyloid and DNA-protein complexes form in the gut, then microbiota stability is maintained, but neurodegenerative and oncological diseases develop
Solution Approach 1:
The patent converts the harmful effect of DNA-protein complex formation into a beneficial outcome by using optimized water compositions to modulate DNase activity, which prevents pathological aggregation while maintaining normal microbiota functions, thereby preventing neurodegenerative and cancerous conditions
3Object-affected harmful factors
If DNase activity is not properly modulated, then bacterial penetration increases, but current compositions cannot prevent this
Solution Approach 1:
The patent optimizes physical-chemical parameters including magnesium concentration (6.0-155.0 mg/l), sodium concentration (0.005-12.0 mg/l), and pH (6.0-7.5) to enhance DNase activity, which in turn reduces bacterial penetration and maintains gut barrier integrity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compositions enhance DNase activity, reducing bacterial penetration, inhibiting neurodegenerative and oncological diseases, and improving metabolic health by enhancing gut barrier integrity.
Implementation Method 1
Compositions comprising magnesium and sodium cations, along with additives like ascorbic acid and plant extracts, are used to modulate DNase activity
Data Source
AI summary
The present invention provides compositions that modulate gut microbiota and/or the activity of deoxyribonucleases (e.g., in the gastrointestinal tract) and are useful in the treatment of diseases and disorders related to the activity of deoxyribonucleases including, for example, neurodegenerative, inflammatory, and metabolic diseases and cancer.