Polysaccharide Hydrogen Sulfide Polymer for Controlled Release
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Solution Overview
Problem
Current hydrogen sulfide releasing compounds face instability in aqueous solutions, leading to uncontrollable release of hydrogen sulfide, and lack controlled release mechanisms suitable for local applications in skin, ocular, and osteoarthritis treatments.
Innovation Solution
Development of polysaccharide-based hydrogen sulfide releasing polymer compounds with at least two substructures capable of releasing hydrogen sulfide through thiol activation, ensuring controlled release in the presence of a thiol group-containing agent, and stability in the absence of such agents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If hydrogen sulfide releasing compounds are dissolved in water, then hydrogen sulfide is released, but the release is uncontrollable and the compound becomes unstable
Solution Approach 1:
The patent introduces a polymer carrier as an intermediary substance that binds hydrogen sulfide releasing compounds. This carrier mediates between the compound and aqueous environment, preventing direct hydrolysis while allowing controlled release through polymer degradation or environmental triggers, thus resolving the contradiction between stability and controlled release
Solution Approach 2:
The patent changes the physical and chemical parameters of the hydrogen sulfide releasing compound by incorporating it into a polymer matrix. This alters the compound's stability profile and release kinetics, transforming it from an unstable, rapidly hydrolyzing substance into a stable, controllably releasing system
2Reliability
If hydrogen sulfide is released for therapeutic application, then therapeutic effect is achieved, but uncontrollable release causes instability
Solution Approach 1:
The patent creates a dynamic release system where the polymer carrier's degradation rate or environmental responsiveness dynamically controls hydrogen sulfide release. This allows the system to adapt release rates to therapeutic needs while maintaining stability during storage and administration
Solution Approach 2:
The patent implements periodic or sustained controlled release through polymer degradation kinetics or environmental triggers, providing steady therapeutic levels of hydrogen sulfide over time rather than uncontrollable immediate release, thus resolving the contradiction between stability and productivity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The polysaccharide-based hydrogen sulfide releasing polymer compounds provide a stable and controlled release of hydrogen sulfide for therapeutic applications, enhancing wound healing, ocular treatments, and osteoarthritis management while maintaining stability in aqueous environments.
Implementation Method 1
substructures (X) capable of releasing hydrogen sulfide by thiol activation
Implementation Method 2
release H2S in the presence of a reaction partner containing a free thiol group
Implementation Method 3
stability in the absence of such agents
Data Source
AI summary
The invention provides a hydrogen sulfide releasing polymer compound having a polysaccharide backbone, wherein the compound has at least two substructures, and wherein said substructures are capable of releasing hydrogen sulfide by thiol activation as well as uses thereof. Additionally, a method of treatment and prevention of a skin condition, an ocular disease or osteoarthritis is provided.