Hyaluronic Acid Binding Peptide Biomaterials for Joint Retention
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Solution Overview
Problem
Current HA-based scaffolds for tissue engineering have limited longevity and retention in joints, leading to ineffective cartilage repair and joint lubrication, as they are rapidly degraded and require frequent injections for maintenance.
Innovation Solution
Development of a biomaterial comprising HA-binding peptides covalently linked to biocompatible polymers, such as PEGDA, which interact with HA to enhance retention and localization within the joint, mimicking natural HA presentation and providing self-healing properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If HA-based scaffolds are used for tissue engineering, then cartilage repair and joint lubrication are achieved, but the scaffolds are rapidly degraded and require frequent injections
Solution Approach 1:
The patent combines HA-binding peptides with biocompatible polymers (such as PEGDA) to create composite biomaterials that integrate the HA-binding capability of peptides with the mechanical strength and stability of synthetic polymers, resolving the contradiction between HA retention and scaffold longevity
Solution Approach 2:
HA-binding peptides serve as intermediaries that anchor HA to the polymer scaffold, preventing rapid degradation and loss of HA while maintaining the structural integrity of the scaffold over extended periods
2Strength
If covalent modification of HA backbone is performed to increase scaffold strength, then mechanical control is improved, but biological activity is significantly changed in unanticipated ways
Solution Approach 1:
The patent segments the scaffold into distinct functional components: HA-binding peptides for biological activity and biocompatible polymers for mechanical strength, avoiding the need to chemically modify the HA backbone itself and thus preserving its natural biological functions
Solution Approach 2:
The biocompatible polymer acts as an intermediary that provides mechanical support without directly modifying HA, allowing the HA to maintain its native structure and biological activity while the polymer delivers the required mechanical properties
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The HA-binding peptide biomaterial improves chondrogenesis, enhances boundary lubrication, and prolongs HA retention, leading to improved cartilage repair and joint health by maintaining HA presence at the tissue surface, reducing inflammation, and protecting cartilage from degradation.
Implementation Method 1
HA-binding peptides have been shown to interact specifically with native HA under physiological condition
Implementation Method 2
HA-binding peptides covalently linked to biocompatible polymers
Implementation Method 3
enhances boundary lubrication, and prolongs HA retention, leading to improved cartilage repair and joint health
Data Source
AI summary
The present invention provides novel biomaterial compositions and methods having a technology to improve retention of hyaluronic acid (HA). The biomaterial compositions utilize small HA binding peptides that is tethered to synthetic biocompatible polymers. When tethered to the polymers, the peptide region allows the polymers to bind to HA. The biocompatible polymers are modified to contain a crosslinking group so that the HA can be incorporated into a scaffold and retained in place. The novel biomaterial 1 compositions can be made into hydrogel compositions and used in a variety of tissue applications, using mild crosslinking conditions and they also have the ability to be degraded with hyaluronidase if needed. Furthermore, the novel biomaterial compositions will enable enhanced interaction between the scaffold and encapsulated cells for a wide variety of tissue engineering applications. Methods of making hydrogel compositions and their use are also provided. The present invention also provides bifunctional biopolymer compositions comprising a biologically compatible polymer having at least one amine reactive moiety and at least one thiol reactive moiety and provides thiolated HA binding peptides which can be used together to coat or chemically modify cartilage or tissues having amine reactive residues with a biologically compatible polymer having HA binding peptides, which allow HA to bind to the surface of the cartilage or tissues. Methods of using same are also provided.