Crosslinked HA-Collagen Hydrogel for Dermal Filler Tissue Integration
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Solution Overview
Problem
Existing dermal fillers based on crosslinked hyaluronic acid and collagen do not promote cellular infiltration and tissue integration, limiting their effectiveness in enhancing aesthetic quality and tissue generation.
Innovation Solution
A crosslinked macromolecular matrix comprising hyaluronic acid and collagen, formed through a controlled crosslinking process using a coupling agent, which promotes cellular migration and tissue formation by forming a biocompatible hydrogel suitable for injection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If crosslinked hyaluronic acid and collagen are used as dermal fillers, then the structural support and volume enhancement are improved, but cellular infiltration and tissue integration are not promoted
Solution Approach 1:
The patent applies porous materials by creating a hydrogel matrix with controlled porosity that allows cellular infiltration. The crosslinked hyaluronic acid and collagen form a three-dimensional network with interconnected pores that facilitate cell migration and tissue integration while maintaining structural support for volume enhancement.
Solution Approach 2:
The patent uses composite materials by combining crosslinked hyaluronic acid and collagen in a hydrogel formulation. This composite structure leverages the structural properties of collagen for strength and the hydrophilic, biocompatible characteristics of hyaluronic acid to promote cellular interaction and tissue integration.
2Duration of action of stationary object
If crosslinking is used to stabilize the hydrogel structure, then the durability and shape retention are improved, but biodegradability and cellular acceptance are reduced
Solution Approach 1:
The patent applies parameter changes by carefully controlling the crosslinking degree and using biocompatible crosslinking agents. The crosslinking density is optimized to balance structural stability for durability with sufficient porosity and biodegradability for cellular acceptance and natural degradation over time.
3Strength
If high concentration of crosslinking agents is used to form the macromolecular matrix, then the gel strength and stability are improved, but cytotoxicity and biocompatibility are worsened
Solution Approach 1:
The patent uses intermediary substances as biocompatible crosslinking agents that mediate the formation of the macromolecular matrix without causing cytotoxicity. These intermediary agents enable sufficient crosslinking for gel strength while being non-toxic to cells and compatible with biological systems.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The crosslinked hydrogel enhances aesthetic quality and stimulates tissue generation, providing improved soft tissue augmentation and integration, suitable for various cosmetic and reconstructive applications.
Implementation Method 1
the hyaluronic acid component is crosslinked to the collagen component by a crosslinking component; and wherein the crosslinking component comprises a plurality of crosslink units, wherein at least a portion of the crosslink units comprise an ester bond or an amide bond
Implementation Method 2
the product comprises a filler comprising a hydrogel having a form suitable for injecting into human tissue; wherein the hydrogel comprises water, and a crosslinked macromolecular matrix
Data Source
AI summary
Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.