Haemostatic Paste Reconstitution via Porous Matrix
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Solution Overview
Problem
Conventional haemostatic paste preparations require mechanical mixing, which is time-consuming, can compromise sterility, and affects the consistency of the paste, making them unsuitable for rapid use in surgical settings where bleeding needs to be controlled efficiently.
Innovation Solution
A dry composition that reconstitutes into a soft, light paste without mechanical mixing by using an alkaline and acidic compound that react to produce gas upon wetting, ensuring a consistent and sterile application.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If mechanical mixing is used to prepare haemostatic paste, then uniformity of composition is achieved, but preparation time increases and sterility may be compromised
Solution Approach 1:
The biocompatible polymer is pre-formed as a porous matrix with controlled pore structure before use. This preliminary preparation eliminates the need for mechanical mixing at the point of use, as the liquid component simply permeates the pre-structured matrix to form a homogeneous paste rapidly without time-consuming agitation
Solution Approach 2:
The mechanical mixing process is replaced by a passive diffusion and permeation mechanism. The liquid component naturally permeates through the porous polymer matrix without requiring mechanical agitation, thereby eliminating the time-consuming mixing step while maintaining composition uniformity through the controlled pore structure
2Stability of the object's composition
If mechanical mixing is performed to form haemostatic paste, then homogeneous composition is achieved, but sterility may be compromised
Solution Approach 1:
Mechanical mixing operations are replaced by passive liquid permeation through the porous polymer matrix. This eliminates the need for syringe transfers, shaking, or stirring that could introduce contaminants, while still achieving homogeneous composition through the controlled pore structure that guides liquid distribution
Solution Approach 2:
The porous polymer matrix itself performs the mixing function through its structure. As liquid permeates through the pores, it automatically distributes throughout the matrix without external mechanical intervention, making the system self-mixing and eliminating sterility risks associated with manual mixing operations
3Stability of the object's composition
If extensive mechanical mixing is used to prepare haemostatic paste, then uniform composition is achieved, but paste consistency is affected
Solution Approach 1:
The polymer matrix is pre-formed with a specifically controlled porous structure that dictates liquid distribution. This preliminary structuring ensures that when liquid is added, it permeates in a controlled manner that preserves the intended paste consistency without the disruptive effects of mechanical mixing
Solution Approach 2:
Mechanical mixing that disrupts paste consistency is replaced by controlled liquid permeation through the porous matrix. The uniform pore structure ensures even liquid distribution without introducing air bubbles or creating heterogeneous textures that mechanical agitation would produce
Data Source
AI summary
The present disclosure relates to a dry composition which reconstitutes without mechanical mixing to form a flowable paste having a soft and light consistency suitable for use in haemostasis and wound healing procedures upon addition of an aqueous medium. The disclosure further relates to methods of preparing the dry composition, methods for reconstituting the dry composition and medical use of the composition.