Halobacillus Lysate Composition for Skin Barrier and Hyaluronic Acid
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Solution Overview
Problem
The skin's natural ability to maintain moisture and elasticity decreases with age due to reduced collagen, elastin, and hyaluronic acid, leading to issues such as wrinkles, sagging, and dryness, and the epidermal layer's barrier is compromised by external stimuli.
Innovation Solution
A composition containing the bacterial lysate of Halobacillus trueperi TCI66207 strain is used to promote hyaluronic acid production, enhance skin cell mitochondrion activity, and stimulate skin cell proliferation, thereby maintaining the skin's corneum layer completeness.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If conventional skincare approaches are used, then basic hydration is maintained, but skin elasticity and firmness deteriorate with age due to reduced collagen, elastin, and hyaluronic acid
Solution Approach 1:
The patent introduces a bacterial lysate as an intermediary substance that mediates between external skincare application and internal skin cell processes. The lysate contains cellular components that act as signaling molecules and nutrients, stimulating skin cells to produce more hyaluronic acid and collagen without directly injecting these substances into the skin.
Solution Approach 2:
The invention enables skin cells to self-produce hyaluronic acid and collagen through stimulation by the bacterial lysate. Instead of relying on external sources of these substances, the skin's own cells are activated to synthesize them, creating a self-sustaining mechanism for maintaining skin elasticity and firmness.
2Ease of operation
If the skin barrier is exposed to external stimuli, then natural skin turnover occurs, but the corneum layer completeness is compromised leading to moisture loss and sensitivity
Solution Approach 1:
The bacterial lysate is applied before environmental damage can occur, preparing the skin barrier in advance. The lysate strengthens the corneum layer and enhances skin cell health proactively, creating a more resilient barrier that can withstand subsequent environmental stressors without compromising completeness.
3Duration of action of stationary object
If natural skin components decrease with age, then skin fullness and elasticity are improved initially, but long-term skin health and water holding ability deteriorate
Solution Approach 1:
The invention establishes a continuous cycle of skin cell renewal and hyaluronic acid production through regular application of the bacterial lysate. This creates an ongoing process that continuously replenishes skin components and maintains water holding ability, counteracting the natural decline that occurs with aging over time.
Data Source
AI summary
A method for maintaining skin corneum layer completeness, promoting hyaluronic acid production, improving skin cell mitochondrion activity and/or promoting skin cell proliferation in a subject in need thereof, includes administering to the subject a composition including bacterial lysate of a H. trueperi TCI66207 strain. The Halobacillus trueperi TCI66207 strain is deposited in Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures under an accession number of DSM 33381.