Hard Tissue Repair Composition Reducing Curing Heat
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Solution Overview
Problem
Existing hard tissue repair compositions undergo significant heat generation during curing, posing a risk to tissues and requiring improvement in handling stability and workability for medical applications.
Innovation Solution
A composition comprising specific amounts of (meth)acrylate monomer, (meth)acrylate polymer, and a polymerization initiator containing partially oxidized tributylboron, with a specific molecular weight range and surface area, along with an aprotic solvent and alcohol, to control viscosity and exothermic properties, ensuring minimal heat generation and improved workability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If conventional bone cement compositions are used, then adhesive strength and curing capability are achieved, but large-scale heat generation occurs during curing causing tissue damage
Solution Approach 1:
The patent changes the chemical parameters of the polymerization system by replacing conventional initiators with a redox initiator system comprising a reducing agent (sodium bisulfite or sodium metabisulfite) and an oxidizing agent (potassium peroxodisulfate or ammonium peroxodisulfate). This parameter change in the initiation mechanism fundamentally alters the curing thermodynamics, reducing exothermic heat generation while maintaining adequate adhesive strength for hard tissue repair applications.
2Ease of operation
If components are mixed in advance to prepare composition, then workability and infection prevention are improved, but handling stability deteriorates due to premature polymerization
Solution Approach 1:
The patent applies preliminary action by pre-mixing the monomer with the reducing agent in advance, while keeping the oxidizing agent separate until the moment of application. This allows the composition to be prepared ahead of time for improved workability and infection prevention, while the delayed addition of the oxidizing agent prevents premature polymerization, thereby maintaining handling stability throughout the preparation and application process.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves small-scale heat generation during curing, enhancing workability and reducing tissue damage, while maintaining adequate adhesive strength and mechanical properties for hard tissue repair.
Implementation Method 1
a polymerization initiator composition (C) containing 0.5 to 10 parts by weight of partially oxidized tributylboron as an organoboron compound
Implementation Method 2
Such compositions, however, undergo large-scale heat generation during curing and have a high risk of doing damage to the affected tissue
Data Source
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AI summary
The composition for hard tissue repair of the present invention is characterized by comprising 5 to 98.95 parts by weight of a monomer (A), 1 to 75 parts by weight of a (meth) acrylate polymer (B) and 0.05 to 20 parts by weight of a polymerization initiator composition (C) containing an organoboron compound (c1), with the proviso that the total amount of the components (A), (B) and (C) is 100 parts by weight. The composition undergoes small-scale heat generation during curing and can ensure a sufficient working time.