HCA Ketone Utilization via fNIRS Feedback
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Solution Overview
Problem
Individuals with suboptimal ketone utilization, particularly those with conditions like Alzheimer's disease and insulin resistance, face challenges in metabolic energy production, leading to potential cell damage and unhealthily low blood oxygen saturation and hemoglobin levels.
Innovation Solution
Administering a therapeutically effective amount of (−)-hydroxycitric acid (HCA) or its salts to increase ketone utilization, thereby enhancing blood oxygen saturation and hemoglobin levels, as evidenced by fNIRS measurements, which can be achieved through formulations like the 'Bolus Dose Shot' containing potassium-magnesium HCA salt.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Use of energy by moving object
If HCA is administered to increase ketone utilization, then energy production efficiency is improved, but blood oxygen saturation and hemoglobin levels were previously unrecognized as affected parameters
Solution Approach 1:
The patent employs fNIRS (functional Near-Infrared Spectroscopy) technology to provide real-time feedback on blood oxygen saturation and hemoglobin levels in the brain. This feedback mechanism allows for the detection and measurement of HCA's effects on these previously unrecognized parameters, enabling monitoring and optimization of ketone utilization therapy.
Solution Approach 2:
The patent replaces traditional mechanical blood sampling methods with optical detection technology (fNIRS). This substitution allows for non-invasive, continuous monitoring of blood oxygen saturation and hemoglobin levels, enabling real-time assessment of HCA's effects without the limitations of conventional mechanical approaches.
2Speed
If HCA formulations are administered rapidly, then therapeutic effect onset is accelerated to 10-15 minutes, but measurement and detection precision requirements increase
Solution Approach 1:
The patent replaces invasive blood sampling with optical detection methods (fNIRS) that can continuously and non-invasively measure blood oxygen saturation and hemoglobin levels. This substitution enables high-precision measurement of rapid physiological changes without the time delays and invasiveness of traditional methods.
Solution Approach 2:
The patent utilizes near-infrared optical detection that measures changes in light absorption related to hemoglobin oxygenation states. This optical approach detects color/absorption changes in blood related to oxygen saturation, providing precise measurement of rapid physiological responses to HCA administration.
Data Source
AI summary
The invention relates generally to the field of medical treatment. More particularly, the invention relates to treating a patient in order to increase the amount of ketones metabolized by mitochondria. Exemplary patients include those with Alzheimer's disease and insulin resistance.