Head-Mounted Iris Tracking for ANS Feedback and Prediction

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Solution Overview

Problem

Current methodologies for denervation and neuromodulation lack adequate feedback, biomarkers for patient selection, and outcome prediction, particularly in treating conditions like drug-resistant hypertension and glucose metabolism abnormalities, and there is a need for unobtrusive monitoring of autonomic nervous system (ANS) activity in virtual and augmented reality environments.

Innovation Solution

A system and method for assessing sympathetic and parasympathetic neural activity by tracking iris features using a head-mounted display (HMD) with back-facing imaging sensors, analyzing iris trajectories, and generating metrics through image processing, combined with stress tests and physiologic monitoring to provide feedback for treatment selection and outcome prediction.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional denervation and neuromodulation methodologies are used, then treatment procedures can be performed, but adequate feedback and outcome prediction are lacking

Engineering Contradiction:

Improvetreatment outcome predictionVSAvoidfeedback information

Core Design Contradiction:

ReliabilityVSLoss of information

Solution Approach 1:

The patent implements real-time feedback systems using wearable sensors that continuously monitor physiologic parameters (heart rate, temperature, galvanic skin response) during denervation and neuromodulation procedures. This feedback is processed to provide immediate information about treatment effectiveness, enabling clinicians to adjust procedures based on actual patient response rather than relying on predetermined protocols alone.

Inventive Principle:

Principle #23Feedback

Solution Approach 2:

The patent employs pre-procedural assessment protocols that evaluate patient-specific physiologic characteristics before denervation or neuromodulation procedures. By analyzing baseline autonomic nervous system function and predicting individual responses to treatment, the system enables personalized treatment planning and outcome prediction before the actual procedure begins.

Inventive Principle:

Principle #10Preliminary action

2Ease of operation

If unobtrusive monitoring of ANS activity is implemented, then patient comfort is improved, but measurement precision may be compromised

Engineering Contradiction:

Improvepatient comfortVSAvoidANS activity measurement

Core Design Contradiction:

Ease of operationVSMeasurement precision

Solution Approach 1:

The patent replaces traditional mechanical or invasive monitoring methods with optical and electrical sensing technologies integrated into wearable devices. These sensors use photoplethysmography, electrodermal activity, and thermal sensing to detect autonomic nervous system changes without physical contact with sensitive areas, maintaining patient comfort while achieving high measurement precision through advanced signal processing algorithms.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Data Source

PatentUS12471776B2ANS assessment systems, kits, and methods

Publication Date: 2025.11.18 AUTONOMIX MEDICAL INC

AI summary

Systems, devices, methods, and kits for monitoring one or more physiologic and/or physical signals from a subject are disclosed. A system including a head mounted display to monitor one or more physiologic signals from the face or head of the subject is disclosed. A method for analyzing an ocular parameter of the subject to determine a sympathetic and a parasympathetic outflow thereto is disclosed.