Heart Model Action Potential Duration Restitution Analysis
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Solution Overview
Problem
Current methods for detecting atrial fibrillation and predicting its likelihood during radiofrequency catheter ablation procedures are inaccurate and costly due to noise in electrocardiogram signals and limited data length, making it difficult to determine the optimal intensity and location for the procedure.
Innovation Solution
A method and device that generate a heart model reflecting action potential duration restitution by calculating the correlation between relaxation period and action potential duration, with a maximum slope visually outputted to specific coordinates, allowing for real-time detection of atrial fibrillation occurrence and likelihood, using a three-dimensional model with 450,000 coordinates and a correlation calculation formula.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Difficulty of detecting and measuring
If time/frequency analysis method using ECG signal is used to detect atrial fibrillation points, then detection capability is improved, but measurement precision deteriorates due to noise and limited data length
Solution Approach 1:
The patent introduces an action potential duration restitution analysis as an intermediary method between raw ECG signals and arrhythmia detection. Instead of directly analyzing noisy ECG signals, the system calculates APD at multiple coordinates and analyzes the restitution relationship (correlation between APD and relaxation period), which serves as a mediator that filters out noise while preserving arrhythmia detection capability.
Solution Approach 2:
The patent transitions from one-dimensional ECG signal analysis to three-dimensional spatial analysis by measuring action potential duration at multiple coordinates (e.g., 450,000 coordinates) throughout the heart model. This dimensional expansion allows detection of spatial patterns of arrhythmia that cannot be detected in traditional ECG signals, improving both detection capability and precision.
2Measurement precision
If time/frequency analysis method is used for arrhythmia detection, then detection accuracy is improved, but device complexity and cost increase
Solution Approach 1:
The patent creates a computational model (three-dimensional heart model with N coordinates) that replicates the electrical behavior of the actual heart. Instead of using complex physical measurement devices, the system uses voltage data from relatively simple arrhythmia tests and processes it through a computational model, achieving high detection accuracy while reducing device complexity and cost.
Solution Approach 2:
The patent replaces complex mechanical/electrical analysis systems with a computational approach. Instead of using sophisticated time/frequency analysis hardware and software, the system uses a computational model that calculates action potential duration and analyzes restitution relationships through mathematical formulas, simplifying the overall system while maintaining or improving detection accuracy.
3Productivity
If radiofrequency catheter ablation procedure is performed without accurate pre-detection, then treatment can be applied, but manufacturing precision deteriorates as optimal intensity and location cannot be determined
Solution Approach 1:
The patent performs preliminary detection and analysis before the radiofrequency catheter ablation procedure. By calculating action potential duration restitution and identifying points where atrial fibrillation occurs or is likely to occur in advance, the system provides precise guidance for the subsequent ablation procedure, ensuring optimal intensity and location selection while maintaining treatment efficiency.
Data Source
AI summary
A method for generating a heart model reflecting action potential duration restitution is provided, which can visually output the maximum slope of the correlation between a relaxation period and an action potential duration at every point included in a three-dimensional heart model.