Heart Tissue Risk Visualization Using Non-Invasive Phase Space Tomography
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Solution Overview
Problem
Current methods for assessing coronary artery blockages and myocardial perfusion require invasive procedures, which are risky, time-consuming, and lack non-invasive tools for identifying high-risk patients and predicting therapeutic success.
Innovation Solution
A non-invasive method using phase space tomography analysis to generate three-dimensional and two-dimensional visualizations of myocardial tissue, overlaid with data identifying myocardium at risk and blocked coronary arteries, facilitated by a graphical user interface for intuitive diagnosis and treatment planning.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If invasive procedures such as coronary angiography are used to measure occlusion size and blood flow, then measurement precision is improved, but patient safety and ease of operation deteriorate due to risks of stroke, heart attack, injury, irregular heart rhythms, kidney damage, infection, and radiation exposure
Solution Approach 1:
The patent replaces invasive mechanical procedures (catheterization, angiography) with non-invasive electrical field-based measurements using body surface potential maps. The electrical field measurements capture cardiac gradient information without physical intrusion into the cardiovascular system, eliminating risks of stroke, heart attack, injury, infection, and radiation exposure while maintaining diagnostic capability.
Solution Approach 2:
The patent uses body surface potentials as an intermediary to indirectly measure coronary artery occlusion characteristics. Instead of directly visualizing vessels or measuring flow with catheters, the system captures electrical field changes on the body surface that correlate with myocardial perfusion and occlusion severity, providing a safe indirect measurement method.
2Measurement precision
If invasive coronary angiography procedures are performed to evaluate blockage severity, then diagnostic accuracy is improved, but time consumption and procedure complexity increase
Solution Approach 1:
The patent substitutes time-consuming invasive angiography procedures with immediate non-invasive electrical field measurements. Body surface potential mapping can be performed rapidly without catheterization, contrast injection, or complex imaging sequences, significantly reducing procedure time while evaluating blockage severity through electrical field analysis.
Solution Approach 2:
The patent performs preliminary assessment of coronary artery disease using non-invasive electrical field measurements before committing to invasive procedures. This preliminary action identifies high-risk patients who need further evaluation, reducing the number of patients requiring time-consuming angiography while maintaining diagnostic accuracy for severe cases.
3Loss of information
If contemporary techniques using cardiac gradient phase-space changes are used to assess coronary disease, then information completeness is improved, but difficulty of detecting and measuring increases due to noise contamination and signal complexity
Solution Approach 1:
The patent extracts relevant diagnostic information from body surface potential signals by focusing on specific electrical field characteristics that correlate with coronary artery occlusion. Instead of analyzing the entire complex cardiac gradient signal, the system isolates and measures specific potential distribution patterns and their changes during stress, filtering out noise and irrelevant information.
Solution Approach 2:
The patent visualizes electrical field changes using color-coded body surface potential maps that display spatial distribution and temporal changes of potentials. This visualization transforms complex electrical signal data into intuitive color patterns that highlight areas of abnormal perfusion and occlusion, making it easier to detect and interpret diagnostic information without getting lost in signal complexity.
Data Source
AI summary
Exemplified methods and systems facilitate presentation of data derived from measurements of the heart in a non-invasive procedure (e.g., via phase space tomography analysis). In particular, the exemplified methods and systems facilitate presentation of such measurements in a graphical user interface, or “GUI” (e.g., associated with a healthcare provider web portal to be used by physicians, researchers, or patients, and etc.) and/or in a report for diagnosis of heart pathologies and disease. The presentation facilitates a unified and intuitive visualization that includes three-dimensional visualizations and two-dimensional visualizations that are concurrently presented within a single interactive interface and/or report.