Heart Valve Deployment Prediction From Intra-Operative Imaging

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Solution Overview

Problem

Minimally invasive heart valve procedures face challenges in predicting the deployment behavior of prosthetic heart valves due to complex, multi-variate factors, leading to issues like malpositioning and obstruction, which current methods fail to address accurately and reliably across different valve types, anatomies, and sizes.

Innovation Solution

A computer-implemented method trains a deployment model using baseline image sequences to predict the intra-operative future deployment state of heart valve prostheses, incorporating heart valve and anatomic characteristics, and employs computational modeling to account for spatiotemporal relations and non-uniform expansions, enabling precise positioning and orientation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If computational modeling is used to predict deployment behavior, then prediction accuracy is improved, but device complexity increases

Engineering Contradiction:
Improveprediction accuracyVSAvoidmodel complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system segments the prediction task into multiple specialized models: a first machine learning model predicts deployment position, a second machine learning model predicts deployment orientation, and a biomechanical model predicts tissue interaction forces. This segmentation allows each model to focus on specific aspects of deployment behavior, improving overall prediction accuracy while managing complexity through modular architecture.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The integrated computational framework serves multiple functions simultaneously: it predicts deployment position, orientation, and tissue interaction forces using the same set of input parameters (valve type, anatomy type, size, delivery system characteristics). This multi-functionality reduces redundancy and manages complexity by reusing the same computational infrastructure for different prediction objectives.

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Manufacturing precision

If multiple operators are required for accurate deployment, then deployment precision is improved, but ease of operation deteriorates

Engineering Contradiction:
Improvedeployment precisionVSAvoidoperational simplicity
Core Design Contradiction:
Manufacturing precisionVSEase of operation

Solution Approach 1:

The system introduces a computational prediction model as an intermediary between the operator and the deployment process. The model acts as a virtual assistant that provides real-time predictions about deployment behavior, allowing a single operator to make informed decisions without needing multiple operators for manual adjustment and monitoring.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The system performs preliminary computational analysis before actual deployment to predict how the valve will behave during deployment. By calculating expected deployment position, orientation, and tissue interaction forces in advance, the system enables operators to plan the deployment strategy beforehand, reducing the need for complex real-time multi-operator coordination.

Inventive Principle:
Principle #10Preliminary action

3Measurement precision

If detailed imaging assessment is used, then measurement precision is improved, but loss of time increases

Engineering Contradiction:
Improveimaging assessment accuracyVSAvoidprocedural time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The system performs detailed computational analysis and generates deployment predictions before the actual deployment procedure. By pre-calculating expected deployment behavior based on patient-specific anatomy and valve characteristics, the system eliminates the need for time-consuming intra-operative imaging adjustments and manual assessments during the critical deployment phase.

Inventive Principle:
Principle #10Preliminary action

Data Source

PatentEP4687154A1A computer-implemented method for training at least one deployment model, a computer program, a non-transitory computer-readable medium, a trained machine-learning model, a computer implemented method for predicting a deployment of a heart valve prosthesis, a medical apparatus, and a method for deploying a heart valve prosthesis
Publication Date: 2026.02.04 CARANX MEDICAL
  • EP4687154A1 patent drawingFigure 1A~1B
  • EP4687154A1 patent drawingFigure 1C~1D
  • EP4687154A1 patent drawingFigure 2A~2C

AI summary

A computer-implemented method for training at least one deployment model to predict a deployment of a heart valve prosthesis assembly (2, 3, 4) comprising the steps of receiving, by one or more processors, a baseline image sequence. The baseline image sequence comprises images which include the heart valve prosthesis assembly (2, 3, 4) within a native anatomic structure (9) in at least two different deployment states. The method includes extracting at least one heart valve prosthesis assembly characteristic of the heart valve prosthesis assembly (2, 3, 4) from the baseline image sequence. The method optionally includes extracting at least one anatomic characteristic of the native anatomic structure (9) from the baseline image sequence. The method comprises training the at least one deployment model for the heart valve prosthesis assembly (2, 3, 4) based on the heart valve prosthesis assembly characteristic, and optionally the anatomic characteristic. The deployment model is configured for predicting an intra-operative future deployment state of a heart valve prosthesis assembly (2', 3', 4') based on an intra-operative image sequence comprising the heart valve prosthesis assembly (2', 3', 4') in a current deployment state.