Heated Blade FFPE Tissue Scraping Device
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Solution Overview
Problem
Existing methods for scraping and collecting FFPE sections from slides are inefficient, leading to waste and contamination due to the manual nature and complexity of the process, which increases costs and time.
Innovation Solution
A sample scraping method and device that heats the FFPE section on a slide, allowing it to be softened and then efficiently scraped and collected using a blade, which adheres to the blade and reduces scattering and contamination.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If manual scraping method is used, then operation simplicity is maintained, but scraping efficiency and recovery rate deteriorate
Solution Approach 1:
The patent applies parameter changes by controlling the temperature of the blade and the properties of the adhesive substance. The blade is heated to a specific temperature range to soften the FFPE section, and an adhesive substance is applied to the blade surface to enhance tissue adhesion during scraping, thereby improving scraping efficiency while maintaining operational simplicity
Solution Approach 2:
The patent introduces an adhesive substance as an intermediary between the blade and the FFPE section. This adhesive substance enhances the bonding between the blade and tissue, allowing for more efficient scraping and recovery without requiring complex manual operations
2Device complexity
If manual scraping method is used, then device complexity is avoided, but tissue scattering and contamination increase
Solution Approach 1:
The patent uses parameter changes by controlling blade temperature and adhesive properties to ensure tissue adheres to the blade during scraping. This prevents tissue scattering and contamination while maintaining a relatively simple device structure without requiring complex containment mechanisms
Solution Approach 2:
The patent converts the potential harm of tissue scattering into a benefit by using thermal energy and adhesive substances to ensure tissue adheres to the blade. The heat softens the tissue for better adhesion, and the adhesive prevents scattering, turning what could be a contamination risk into an efficient recovery process
3Productivity
If heating is applied to soften tissue, then scraping smoothness improves, but energy consumption increases
Solution Approach 1:
The patent applies parameter changes by controlling the heating temperature within an optimal range and using adhesive substances to enhance tissue adhesion. This allows for effective scraping smoothness improvement with moderate energy input, as the adhesive substance works synergistically with thermal softening to reduce the energy required for scraping
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method and device enable stable and smooth scraping and recovery of FFPE sections without waste, reducing contamination and user burden by ensuring the collected tissue adheres to the blade and is efficiently transferred to a container.
Implementation Method 1
heating the FFPE section (121) held on a slide (120)
Data Source
AI summary
A sample scraping method and a sample scraping device capable of efficiently scraping and collecting a biological tissue section without waste while suppressing contamination is provided. In a sample scraping method for scraping and collecting a biological tissue section held on a slide, the FFPE section held on the slide is heated, and the heated FFPE section is scraped by a blade such that the FFPE section that has been scraped off and remains on the blade is collected in a container.