Heated Chemical Solution for Accelerated Bone Tissue Regeneration
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Solution Overview
Problem
Existing methods for bone tissue regeneration, such as those involving etidronic acid, calcium chloride, gadolinium nitrate, and dysprosium chloride, take a relatively long time to restore normal physiological function to injured bones, necessitating a faster regeneration process.
Innovation Solution
A water solution containing etidronic acid, calcium chloride, gadolinium nitrate, and dysprosium chloride is heated to a temperature of 30-100°C for 1-48 hours and then cooled to room temperature before application to the fracture site, significantly accelerating bone tissue regeneration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a water solution containing etidronic acid, calcium chloride, gadolinium nitrate, and dysprosium chloride is introduced into the fracture area at room temperature, then bone tissue regeneration occurs, but the process takes a relatively long time
Solution Approach 1:
The patent applies parameter changes by heating the water solution to a temperature of 30-100°C before introduction into the fracture area. This temperature parameter modification activates the bone regeneration process significantly faster than room temperature application, reducing regeneration time by 15-20% while maintaining the effectiveness of the chemical components (etidronic acid, calcium chloride, gadolinium nitrate, and dysprosium chloride).
Solution Approach 2:
The patent implements preliminary action by pre-heating the water solution to 30-100°C before its introduction into the fracture area. This preparatory thermal treatment activates the regenerative properties of the solution components, enabling faster bone tissue regeneration when the solution is applied to the fracture site.
2Productivity
If the water solution is heated to 30-100°C and kept at this temperature for 1-48 hours, then bone tissue regeneration time is reduced by 15-20%, but additional energy and time are required for heating and maintenance
Solution Approach 1:
The patent utilizes parameter changes by optimizing the temperature range (30-100°C) and holding time (1-48 hours) to achieve maximum regenerative effect. This controlled thermal parameter modification accelerates bone tissue regeneration by 15-20% while allowing flexibility in energy investment based on clinical requirements.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method reduces the bone tissue regeneration time by 15-20% compared to previous methods, allowing for quicker restoration of normal physiological function without requiring special equipment and can be performed under outpatient conditions.
Implementation Method 1
it is first, according to the invention, brought to a temperature of (30 - 100) ° C, kept at this temperature for (1 - 48) hours and then cooled back to room temperature
Data Source
AI summary
To shorten the duration of bone tissue regeneration at a bone injury or defect site, as well as the recovery time, a bone tissue regeneration procedure is used in which fragments of an injured bone are immobilized with a plaster cast or a plastic bandage. An aqueous solution is then injected into the fracture area. This solution contains 1-hydroxyethylidene diphosphonic acid at a concentration of (1.80–2.06) g/l, anhydrous calcium chloride at a concentration of (1.44–2.22) g/l, gadolinium nitrate(III) hexahydrate at a concentration of (0.30–0.40) g/l, dysprosium chloride(III) hexahydrate at a concentration of (0.038–0.076) g/l, and has a pH of (7.3–7.8). According to the invention, the aforementioned aqueous solution is heated to a temperature of (30 - 100)°C before being injected into the fracture area, held at this temperature for (1 - 48) hours and then cooled back down to room temperature.