Heating Element Integrated Extraction Nucleic Acid Device

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Solution Overview

Problem

Existing methods for extracting and amplifying nucleic acids are complex and time-consuming, requiring significant labor and time before the extracted nucleic acid can be amplified.

Innovation Solution

A method and device that utilize a heating element bonded or connected to an extraction nucleic acid, which is at least partly complementary to the nucleic acid to be extracted. The heating element is used to bring the nucleic acid into contact with a reaction solution and heat it to a temperature equal to or higher than the denaturing temperature of the nucleic acid, allowing for rapid extraction and amplification.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If traditional extraction methods are used, then nucleic acid can be extracted, but the process is complex and time-consuming

Engineering Contradiction:

Improveextraction speedVSAvoidextraction process complexity

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The heating element and extraction nucleic acid are combined into a single integrated device. The heating element serves dual purposes: it heats the reaction solution to denaturing temperatures and provides a surface for the extraction nucleic acid to bind, eliminating the need for separate extraction and amplification equipment

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The heating element performs multiple functions: (1) heating the reaction solution to denaturing temperature, (2) providing a binding surface for extraction nucleic acid, and (3) enabling both extraction and amplification processes in one device, thereby reducing device complexity while improving productivity

Inventive Principle:

Principle #6Universality (Multi-functionality)

2Loss of time

If traditional extraction methods are used, then nucleic acid can be extracted, but significant time is required before amplification

Engineering Contradiction:

Improvetime before amplificationVSAvoidoverall process efficiency

Core Design Contradiction:

Loss of timeVSProductivity

Solution Approach 1:

The extraction nucleic acid is pre-bound to the heating element before the reaction solution is added. This preliminary preparation allows immediate extraction upon contact with the sample, eliminating preparation time and enabling faster transition to the amplification phase

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

By combining extraction and amplification into a single continuous process on the same heating element, the patent eliminates the time gap between extraction completion and amplification start, thereby reducing total time loss and improving overall productivity

Inventive Principle:

Principle #5Merging (Combining)

3Ease of operation

If separate devices are used for extraction and amplification, then each function can be optimized, but the process requires more labor and equipment

Engineering Contradiction:

Improveoperational simplicityVSAvoidnumber of devices

Core Design Contradiction:

Ease of operationVSDevice complexity

Solution Approach 1:

The heating element is designed as a universal platform that performs both extraction and amplification functions. The extraction nucleic acid bound to the heating element enables extraction, while the heating capability enables amplification, reducing the number of devices needed and simplifying operation

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent merges extraction and amplification devices into a single integrated system. The heating element serves as the common platform for both processes, eliminating the need for separate equipment and reducing operational complexity despite maintaining functional optimization

Inventive Principle:

Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method enables rapid extraction and amplification of nucleic acids, reducing the time and labor required, and allowing for the use of a single device for both extraction and amplification, thereby streamlining the process.

Implementation Method 1

heating the heating element to a temperature that is equal to or higher than a denaturing temperature of the nucleic acid bound to the extraction nucleic acid

Methodology Applied

Scientific EffectHeating: Heating

Implementation Method 2

the extraction nucleic acid is at least partly complementary to the nucleic acid to be extracted from the sample liquid

Methodology Applied

Scientific EffectHybridization:

Data Source

PatentUS12305165B2Device for extracting a nucleic acid from a sample liquid

Publication Date: 2025.05.20 HP HEALTH SOLUTIONS GERMANY GMBH

AI summary

A device for extracting a nucleic acid from a sample liquid includes a heating element configured to be connected to an extraction nucleic acid. The extraction nucleic acid is at least partly complementary to the nucleic acid to be extracted from the sample liquid. The heating element is heatable to a temperature that is equal to or higher than a denaturing temperature of the nucleic acid bound to the extraction nucleic acid.