Hedera helix and Coptis chinensis extract composition for diabetic complications
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Solution Overview
Problem
Current treatments for diabetic complications such as diabetic retinopathy, nephropathy, and angioedema are limited in effectiveness, with no therapeutic agents available to completely cure these conditions, and existing therapies often result in fatal visual impairment or require high-priced interventions.
Innovation Solution
A pharmaceutical and health functional food composition containing a mixed extract of Hedera helix leaves and Coptis chinensis, optionally combined with extracts of Rheum palmatum, Puerariae radix, Ginkgo leaves, Cassiae semen, blueberry, bilberry, or grape seeds, which inhibits the formation of advanced glycation endproducts, vascular endothelial growth factor, and blood-retinal barrier breakage, thereby preventing and treating diabetic complications and angioedema.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments for diabetic complications are used, then some symptomatic relief may be achieved, but the progression of blindness and other complications cannot be completely prevented
Solution Approach 1:
The patent applies preliminary action by administering the herbal composition before diabetic complications fully develop or progress to severe stages. The composition prevents the formation of advanced glycation endproducts and inhibits vascular endothelial growth factor production proactively, thereby preventing blood-retinal barrier breakage and subsequent blindness progression before it occurs
Solution Approach 2:
The patent converts harmful factors into beneficial effects by using natural herbal extracts that counteract the harmful pathways of diabetic complications. The composition transforms the harmful accumulation of advanced glycation endproducts and excessive vascular endothelial growth factor into a controlled state through inhibition, thereby preventing tissue damage and blindness progression
2Reliability
If laser treatment or surgery of vitreous body is performed, then some vision preservation may be achieved, but the treatment is insufficient to completely prevent blindness progression
Solution Approach 1:
The patent introduces an intermediary substance - the herbal composition containing Hedera helix and Coptis chinensis extracts - that mediates between the diabetic condition and the retinal damage. This intermediary prevents the direct harmful interaction by inhibiting the formation of advanced glycation endproducts and blocking vascular endothelial growth factor, thereby preventing blood-retinal barrier breakage without requiring invasive laser or surgical intervention
3Reliability
If no therapeutic agents are available for angioedema and macular edema, then natural disease progression occurs, but pharmaceutical drugs similar to antioxidants provide limited relief
Solution Approach 1:
The patent applies parameter changes by modifying the biochemical parameters involved in angioedema and macular edema. The herbal composition changes the concentration levels of advanced glycation endproducts and vascular endothelial growth factor, thereby altering the permeability parameters of blood vessels and lymphatic ducts to prevent excessive tissue fluid leakage and accumulation
Data Source
AI summary
The present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema containing a mixed extract of Hedera helix leaves and Coptis chinensis as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema further containing an extract of Rheum palmatum, Puerariae radix, Ginkgo leaves, Cassiae semen, blueberry, bilberry, raspberry, or grape seeds as an active ingredient, in addition to the mixed extract of Hedera helix leaves and Coptis chinensis.