Helical Nerve Cuff With Integrated Wireless Electrodes

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Current methods for controlling abnormal physiological activity through the peripheral nervous system are invasive, prone to complications, and limited by the size and accessibility of existing nerve cuffs, which restrict their application to certain nerves and require external devices, leading to risks of infection and displacement.

Innovation Solution

A helical nerve cuff with integrated electrodes and a wireless communication system that can wrap around small or difficult-to-access nerves, allowing for both detection of electrophysiological signals and emission of electrical pulses, and is powered by ultrasonic or radiofrequency waves, enabling implantation in small spaces without external leads.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional electrodes with long leads are implanted, then nerve stimulation can be achieved, but the risk of infection and displacement increases

Engineering Contradiction:
Improverisk of infection and displacementVSAvoidstructure of electrodes and leads
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent merges the electrode structure directly into the nerve cuff, eliminating the need for separate long leads. The electrodes are integrated within the cuff assembly that wraps around the nerve, creating a unified implantable unit that reduces infection risk and displacement while maintaining nerve stimulation capability

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The patent extracts the electrode function from the traditional external device and relocates it within the implantable nerve cuff. By taking out the electrode concept and placing it directly in contact with the nerve within the cuff, the system eliminates the need for external leads and reduces the associated risks

Inventive Principle:
Principle #2Taking out (Extraction)

2Ease of operation

If wholly implantable devices are developed, then invasiveness is reduced, but the device size becomes too large for many body locations

Engineering Contradiction:
Improveinvasiveness of implantationVSAvoidsize of implantable device
Core Design Contradiction:
Ease of operationVSVolume of moving object

Solution Approach 1:

The patent employs a flexible, thin-walled cuff structure that can conform to small nerve diameters. The flexible material allows the device to be implanted in confined body spaces while maintaining the necessary electrode contact area for effective nerve stimulation

Inventive Principle:
Principle #30Flexible shells and thin films

Solution Approach 2:

The patent transitions from a traditional three-dimensional bulky device to a two-dimensional thin-film cuff structure. This dimensional change allows the implantable device to be compressed to fit within small body cavities and around thin nerves, reducing volume while preserving functional capabilities

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

3Ease of manufacture

If nerve cuffs are designed for larger or easily accessible peripheral nerves, then implantation is simplified, but they cannot be used on small or difficult-to-access nerves

Engineering Contradiction:
Improveease of implantationVSAvoidapplicability to different nerve sizes
Core Design Contradiction:
Ease of manufactureVSAdaptability or versatility

Solution Approach 1:

The patent employs adjustable parameters including expandable cuffs with adjustable expansion ratios, variable electrode spacing, and configurable stimulation contact areas. These parameter changes allow the same basic cuff design to adapt to different nerve diameters and anatomical locations, maintaining ease of implantation while expanding versatility

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent creates a universal nerve cuff design that can function on multiple nerve types and sizes through adjustable features. The same basic cuff structure can be configured for different applications by modifying expansion ratios, electrode arrangements, and contact parameters, eliminating the need for nerve-specific custom devices

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The helical nerve cuff provides a more versatile and safer means of controlling nerve activity, reducing the risk of infection and displacement, and allowing for more precise stimulation of smaller nerves, enhancing treatment options for various medical conditions.

Implementation Method 1

the wireless communication system is configured to receive ultrasonic waves or radiofrequency waves, and convert energy from the ultrasonic waves or radiofrequency waves into an electrical energy that powers the device

Methodology Applied
Scientific EffectUltrasonic wave energy conversion: Ultrasonic Vibration

Implementation Method 2

the wireless communication system comprises a radiofrequency antenna

Methodology Applied
Scientific EffectRadiofrequency energy conversion: Electromagnetic Induction

Data Source

PatentEP4045133B1Helical nerve cuff and related implantable devices
Publication Date: 2024.12.25 IOTA BIOSCIENCES INC
  • EP4045133B1 patent drawingFigure 1A~1C
  • EP4045133B1 patent drawingFigure 1D~1F
  • EP4045133B1 patent drawingFigure 2A~2C

AI summary

A helical nerve cuff and an implantable device comprising the helical nerve cuff and a body comprising a wireless communication system are described herein. The implantable device can include a body having a wireless communication system: electrodes that can detect an electrophysiological signal transmitted by a nerve or emit an electrical pulse to the nerve; and a helical nerve cuff. Also described are methods of implanting the helical nerve cuff and the implantable device, as well as methods of making the helical nerve cuff and the implantable device.