Hemispherical Ultrasound Phased Array for Brain Drug Delivery
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Solution Overview
Problem
Current focused ultrasound systems for brain surgery lack precision in focusing low-frequency ultrasound, leading to suboptimal medical efficiency and inability to effectively penetrate deep tissue, limiting their therapeutic effectiveness.
Innovation Solution
A multiple-channel hemispherical focused ultrasound phased array system with a graphic user interface, digital phase control, phase and wave generator, and phase adjustment circuit, allowing for precise phase adjustment and energy control across multiple elements, enhancing focusing efficiency and flexibility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Length of stationary object
If low-frequency ultrasound is used for deep tissue penetration, then penetration depth is improved, but focusing precision deteriorates
Solution Approach 1:
The patent divides the ultrasound system into multiple independent channels (phased array elements) that can be controlled separately. Each element can be individually phased and amplitude-modulated to achieve precise focusing of low-frequency ultrasound waves at the target site, overcoming the natural diffraction limitations of low-frequency waves.
Solution Approach 2:
The patent applies different phase and amplitude characteristics to different elements of the ultrasound array based on their specific positions. This allows each element to contribute optimally to the focal point, creating a concentrated energy focus despite using low-frequency waves for deep penetration.
2Device complexity
If single focused ultrasound system is used, then system simplicity is improved, but therapeutic effectiveness deteriorates
Solution Approach 1:
The patent combines multiple ultrasound channels into a single phased array system, merging their effects to achieve superior therapeutic outcomes. The multiple channels work together in coordination through phase control to produce enhanced focusing capability and therapeutic effectiveness compared to a single channel system.
Solution Approach 2:
The phased array system serves multiple functions: it can focus ultrasound at different locations by adjusting phase relationships, control energy distribution across multiple focal points, and adapt to different treatment requirements, thereby achieving high therapeutic effectiveness while maintaining relatively simple system architecture.
3Manufacturing precision
If phase adjustment circuit is added to improve focusing efficiency, then focusing precision is improved, but device complexity increases
Solution Approach 1:
The patent replaces mechanical focusing mechanisms with electronic phase adjustment circuits. Instead of physically moving or adjusting components to achieve focusing, the system uses electronic phase control to dynamically adjust the phase of each channel, achieving precise focusing through software-controlled signal processing rather than mechanical means.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system achieves improved focusing precision and efficiency, reducing manufacturing costs and increasing the practicality of ultrasound phased arrays, enabling more effective thermal ablation and drug delivery therapies with enhanced flexibility and reduced development risks.
Implementation Method 1
a method and device used in the focused ultrasound system, its wave is transmitted from a phased array to a spherical limitation object, so that it can reach to a preset focus at the same time and in the same phase
Implementation Method 2
After the target tissue absorbs the energy focused by the ultrasound, the temperature of local part can raise 30° C. to 55° C. in a short time. The target tissue will be necrosed and coagulated
Implementation Method 3
the cavitation effect caused by the focused ultrasound system can open the blood-brain barrier temporarily
Data Source
AI summary
The invention is to a biomedical used multiple-channel hemispherical focused ultrasound phased array apparatus. The invention comprises of a graphic user interface, digital multiple channel phase control kernel, multiple channel driving system, and impedance matching module, power feedback device, as well as the hemispherical low-frequency ultrasound phased array. The invention also serves as a good platform reference to develop a focused ultrasound system in the assisted brain drug delivery application.