Hemocompatible Porous Polymer Bead Sorbent for Endotoxin Removal
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current endotoxin adsorbers face challenges such as potential leaching of harmful substances, limited effectiveness in reducing endotoxin levels, and inability to simultaneously remove cytokines and inflammatory mediators, which can lead to sepsis and multiple organ dysfunction syndrome.
Innovation Solution
A novel sorbent material with a net neutral charge covalently attached to a polymeric matrix, capable of retaining endotoxins through tortuous paths and pore capture, while being hemocompatible and able to remove cytokines and inflammatory protein moieties, synthesized using polyol or zwitterionic groups on a poly(styrene-co-divinylbenzene) backbone.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If Polymyxin B is used for endotoxin removal, then endotoxin binding affinity is improved, but potential leaching of harmful substances occurs
Solution Approach 1:
The patent extracts the harmful leaching issue by using a porous polymer matrix that physically confines the Polymyxin B molecules, preventing their release into the bloodstream while maintaining binding affinity for endotoxins
Solution Approach 2:
The patent employs a porous polymer matrix with controlled pore sizes that allows endotoxin molecules to enter and bind to Polymyxin B while preventing the polymer and bound complex from leaching into circulation
2Reliability
If conventional endotoxin adsorbers are used, then endotoxin removal is achieved, but cytokines and inflammatory mediators cannot be simultaneously removed
Solution Approach 1:
The patent creates a multi-functional sorbent where the porous polymer matrix simultaneously removes endotoxins, cytokines, and inflammatory mediators through a single device, eliminating the need for multiple separate treatments
3Quantity of substance
If existing sorbent materials are used, then endotoxin levels are reduced, but harmful substances may be leached causing additional toxicity
Solution Approach 1:
The patent employs a disposable hemofilter with a porous polymer matrix that is discarded after single use, eliminating the risk of harmful substance leaching from reusable materials and ensuring patient safety
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sorbent effectively decreases endotoxin levels without leaching harmful substances, exhibits minimal thrombogenicity, and simultaneously removes cytokines and inflammatory mediators, providing a safer and more comprehensive treatment for endotoxemia.
Implementation Method 1
A novel sorbent material with a net neutral charge covalently attached to a polymeric matrix, capable of retaining endotoxins through tortuous paths and pore capture
Implementation Method 2
retaining endotoxins through tortuous paths and pore capture
Implementation Method 3
able to remove cytokines and inflammatory protein moieties
Data Source
AI summary
The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules.