Hemoglobin AGEs Optical Sensor Using Intersecting Axes
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods for measuring advanced glycation end products (AGEs) in diabetes management are cumbersome, time-consuming, and not suitable for self-testing at home, as they rely on complex techniques like ELISA, which are not practical for general use.
Innovation Solution
A hemoglobin advanced glycation end products measuring instrument that includes a measuring base, a microcuvette, a light emitting unit, a first photosensitive assembly, a second photosensitive assembly, and a processor, which uses intersecting optical axes and specific wavelengths to measure fluorescence and calculate AGEs levels, enabling portable and user-friendly testing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If ELISA test is used to measure advanced glycation end products, then measurement accuracy is improved, but operation complexity and time consumption increase significantly
Solution Approach 1:
The patent replaces the complex mechanical ELISA testing system with an optical detection system. The measuring instrument uses a light source to illuminate the test liquid in the microcuvette, and photosensitive assemblies detect the transmitted light and fluorescence signals. This substitution of mechanical/chemical ELISA procedures with optical detection simplifies the operation while maintaining measurement capability for advanced glycation end products
Solution Approach 2:
The patent changes the measurement parameter from the complex ELISA chemical reaction process to optical parameters (light transmission intensity and fluorescence intensity). By measuring the intensity of transmitted light and fluorescence at specific wavelengths, the instrument directly quantifies advanced glycation end products without requiring the multi-step ELISA procedure, thus reducing operational complexity while preserving measurement accuracy
2Measurement precision
If ELISA test is used to measure advanced glycation end products, then measurement accuracy is improved, but testing time increases
Solution Approach 1:
The patent replaces the time-consuming mechanical ELISA procedure with a rapid optical detection system. The light source and photosensitive assemblies enable direct measurement of advanced glycation end products through light transmission and fluorescence detection, eliminating the need for prolonged incubation, washing, and colorimetric development steps required in ELISA, thus significantly reducing testing time while maintaining accuracy
Solution Approach 2:
The patent skips the lengthy intermediate steps of the ELISA protocol (such as multiple incubation periods, washing steps, and substrate reactions) by directly measuring the optical properties of the test liquid. The instrument rapidly captures light transmission and fluorescence signals to calculate advanced glycation end products concentration, effectively rushing through the measurement process to achieve quick results without sacrificing precision
3Measurement precision
If traditional measuring methods are used, then measurement capability is sufficient, but ease of operation deteriorates for self-testing
Solution Approach 1:
The patent replaces complex mechanical testing procedures with a simplified optical measurement system that requires minimal user intervention. The instrument automatically illuminates the test liquid, detects optical signals, and calculates results, making it easy for users to perform self-testing at home while maintaining the capability to accurately measure advanced glycation end products
Solution Approach 2:
The measuring instrument is designed to be self-operating, automatically performing illumination, detection, signal processing, and result calculation without requiring users to perform complex manual operations. The device enables ordinary users to conduct their own diabetes monitoring by simply placing the test liquid in the microcuvette and pressing a button, thus dramatically improving ease of operation while preserving measurement precision
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The instrument provides a rapid and accurate measurement of AGEs levels, allowing for effective tracking of glycated rates in organs and tissues, facilitating better diabetes management and reducing the risk of complications.
Implementation Method 1
The light emitting unit is positioned at one end of the first optical axis of the measuring base, and outputs parallel light beam along the first optical axis when being driven
Implementation Method 2
The parallel light beam irradiates the to-be-tested liquid to generate fluorescence, and a transmission light beam is towards the other end of the first optical axis
Implementation Method 3
The first photosensitive assembly is positioned at the other end of the first optical axis of the measuring base, and receives and converts the transmission light beam with a first preset wavelength into a first light intensity
Implementation Method 4
The second photosensitive assembly is positioned at one end of the second optical axis, and receives and converts the fluorescence with a second preset wavelength into a second light intensity
Data Source
AI summary
A hemoglobin advanced glycation end products measuring instrument includes a measuring base, a measuring container, a light emitting unit, a first photosensitive assembly, a second photosensitive assembly, and a processor. The light emitting unit outputs parallel light beam when being driven. The parallel light beam irradiates to-be-tested liquid in the measuring container to generate fluorescence and a transmission light beam. The first photosensitive assembly is positioned at the first optical axis, and receiving and converting the transmission light beam with a first preset wavelength into first light intensity. The second photosensitive assembly is positioned at the second optical axis, and receiving and converting the fluorescence with a second preset wavelength into a second light intensity. The processor obtains a hemoglobin advanced glycation end products measuring result according to the first light intensity, the second light intensity, the first standard intensity and the first empty intensity.