Hemoglobin-Guided Fluid Administration After Anaesthesia

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current methods for intravenous fluid administration during anesthesia are inadequate, leading to either fluid overload or underfilling, resulting in complications such as tissue edema, renal dysfunction, and increased infection risk, due to the difficulty in accurately determining the required blood volume and fluid balance.

Innovation Solution

A system using a processor to calculate baseline and target blood volumes based on hemoglobin data, adjusting for dilution and fluid loss, to optimize fluid administration and maintain circulating blood volume accurately.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional intravenous fluid delivery methods are used to maintain blood volume, then blood flow and organ perfusion are restored, but fluid overload occurs resulting in tissue edema and postoperative complications

Engineering Contradiction:

Improveorgan perfusionVSAvoidfluid overload

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The system continuously monitors haemoglobin concentration and uses this feedback to dynamically adjust fluid administration. The processor compares current haemoglobin levels with baseline values to calculate blood volume changes, providing real-time guidance on fluid delivery rates to maintain optimal blood volume without overload

Inventive Principle:

Principle #23Feedback

Solution Approach 2:

The system changes the parameter of fluid delivery rate based on measured haemoglobin concentration. By calculating the relationship between haemoglobin dilution and blood volume expansion, the system adjusts infusion rates to match actual physiological needs rather than using fixed protocols

Inventive Principle:

Principle #35Parameter changes

2Object-generated harmful factors

If restrictive fluid administration is used to achieve fluid balance, then fluid overload is reduced, but blood flow and pressure drop leading to organ dysfunction

Engineering Contradiction:

Improvefluid balanceVSAvoidblood flow

Core Design Contradiction:

Object-generated harmful factorsVSReliability

Solution Approach 1:

The system uses continuous haemoglobin monitoring to provide feedback on blood volume status. This enables dynamic adjustment of fluid delivery to maintain adequate blood flow while avoiding overload, rather than using static restrictive protocols

Inventive Principle:

Principle #23Feedback

Solution Approach 2:

The system replaces mechanical/empirical fluid delivery methods with a computational approach using haemoglobin-based calculations to determine optimal fluid administration, substituting guesswork with quantitative physiological modeling

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

3Stress or pressure

If fluid administration is based solely on mean arterial pressure, then blood pressure is maintained, but accurate blood volume assessment is lost leading to excess fluid delivery

Engineering Contradiction:

Improvemean arterial pressureVSAvoidblood volume

Core Design Contradiction:

Stress or pressureVSMeasurement precision

Solution Approach 1:

The system introduces haemoglobin concentration as an intermediary parameter to assess blood volume. Haemoglobin serves as a marker that reflects changes in blood volume more accurately than blood pressure alone, enabling precise calculation of blood volume status

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The system substitutes blood pressure-based fluid delivery with a haemoglobin-based computational system that directly calculates blood volume, replacing indirect pressure monitoring with direct volume assessment through haemoglobin dilution measurement

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Reduces the risk of fluid overfilling and underfilling by providing precise control over fluid delivery, minimizing complications and maintaining optimal organ perfusion.

Implementation Method 1

The processor is configured to calculate a baseline blood volume (BBV) of the patient. The processor is configured to, after administration of the anaesthetic, calculate a target blood volume (TBV). The processor is configured to calculate the target blood volume (TBV) by comparing the monitored patient haemoglobin data before the administration of the anaesthetic with the monitored patient haemoglobin data after the administration of the anaesthetic

Methodology Applied

Scientific EffectHaemoglobin dilution:

Data Source

PatentEP4564360B1Management of fluid administration

Publication Date: 2026.01.28 TOB1 CONSULTING LTD

Figure 1
Figure 2
Figure 3

AI summary

A system (100) and method (1000) for managing fluid administration to a patient (120) following administration of an anaesthetic. The system (100) comprises a processor (112) configured to receive monitored patient haemoglobin data before and after the administration of the anaesthetic. The processor (112) is configured to calculate a baseline blood volume (BBV) of the patient (120). After administration of the anaesthetic, the processor (112) is configured to calculate a target blood volume (TBV), wherein the target blood volume (TBV) is calculated by comparing the monitored patient haemoglobin data before and after the administration of the anaesthetic.