Hemoglobin Interference Correction in Blood Test Apparatus
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Solution Overview
Problem
Existing blood measurement techniques are unreliable due to the interference of hemoglobin, which can lead to inaccurate concentration measurements of specific components in blood plasma or serum, particularly when hemolysis occurs.
Innovation Solution
A method and apparatus that measure and correct for the absorbance of hemoglobin in a sample by using specific wavelengths of light and pre-stored equations to calculate and subtract the variation of the target's absorbance caused by hemoglobin, ensuring accurate concentration measurements.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If hemoglobin is present in blood plasma or serum at a certain concentration or higher due to hemolysis or the like, then the concentration of a specific component to be detected is higher than an actual value thereof, but measurement reliability deteriorates
Solution Approach 1:
The patent extracts and measures the absorbance of hemoglobin separately from the target component. By using specific wavelengths (450 nm, 535 nm, 630 nm) and pre-stored equations, the system isolates hemoglobin's contribution to the total absorbance, allowing it to be removed from the measurement calculation to obtain the true target concentration.
Solution Approach 2:
The patent utilizes changes in absorbance parameters at different wavelengths to differentiate between hemoglobin and target component. By measuring absorbance at multiple specific wavelengths and applying mathematical equations, the system transforms the mixed absorbance signal into separate contributions from hemoglobin and target, enabling accurate correction.
2Measurement precision
If multiple wavelengths of light are used to measure absorbance, then measurement accuracy improves, but device complexity increases
Solution Approach 1:
The patent employs a multi-functional light detection module that can detect light at multiple wavelengths (450 nm, 535 nm, 630 nm) using the same physical component. This universal detector handles all wavelength measurements without requiring separate detection systems, thereby improving measurement accuracy while minimizing the increase in device complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach provides reliable and accurate measurements of target concentrations by minimizing the impact of hemoglobin, resulting in consistent and precise detection results even in the presence of varying hemoglobin levels.
Implementation Method 1
measuring an absorbance of hemoglobin in a sample, measuring an absorbance of a target in the sample
Data Source
AI summary
A test apparatus and method for measuring a concentration of a target by correcting for an impact of hemoglobin are provided. The target measurement method includes measuring an absorbance of hemoglobin in a sample, measuring an absorbance of a target in the sample, determining variation of the absorbance of the target according to the measured absorbance of the hemoglobin, and correcting the absorbance of the target by subtracting the determined variation of the absorbance of the target from the measured absorbance of the target.