Hemoperfusion Adsorbent Microparticle Removal via Mesh Filtration
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Solution Overview
Problem
Current direct hemoperfusion adsorbers face challenges in safely removing water-insoluble microparticles, requiring special granulation or coating processes that increase production costs and complexity, while existing solutions lack specification on particle diameter distribution and mesh opening sizes for effective microparticle removal.
Innovation Solution
A direct hemoperfusion adsorber using a water-insoluble carrier with a number average particle diameter of 300 μm to 600 μm and a coefficient of variance in particle diameter distribution of 10% to 20%, where water-insoluble microparticles are removed using a mesh with a ratio of mesh opening size for removal to adsorber mesh opening size between 1.3 and 1.5, allowing for safe and efficient production without special equipment or coatings.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a uniform particle diameter distribution adsorbent is used to remove water-insoluble microparticles, then microparticle removal is effective, but a special granulation apparatus is required increasing production complexity
Solution Approach 1:
The invention changes the particle diameter distribution parameters from uniform (conventional) to a specific non-uniform distribution (300-600 μm with 10-20% coefficient of variance). This parameter change allows effective microparticle removal without requiring special granulation apparatus, as the specific distribution enables microparticles to be trapped in inter-particle spaces during normal operation
Solution Approach 2:
The invention uses readily available water-insoluble carriers with standard particle size distributions instead of requiring expensive special granulation equipment. The adsorbent can be produced using conventional equipment, making the process more accessible and cost-effective while still achieving therapeutic safety
2Reliability
If a coating is applied to the adsorbent to prevent water-insoluble microparticle release, then microparticle release is reduced, but the production process becomes complicated
Solution Approach 1:
Instead of adding a coating layer to prevent microparticle release, the invention extracts/removes water-insoluble microparticles from the adsorbent through a specific washing process using a mesh filter. The mesh size is carefully selected to retain microparticles while allowing the adsorbent to pass through, eliminating the need for complex coating processes
Solution Approach 2:
The invention changes the approach from modifying the adsorbent surface (coating) to modifying the particle size distribution and using a mesh filter with specific parameters. The mesh opening size is set to 1.3-1.5 times the adsorber mesh opening size, creating optimal conditions for microparticle removal without requiring coating materials or equipment
3Ease of manufacture
If general-purpose water-insoluble carriers are used without special processing, then production is simpler, but water-insoluble microparticles may enter the patient's body
Solution Approach 1:
The invention performs preliminary removal of water-insoluble microparticles from the adsorbent before the adsorber is assembled and used. A washing process using a mesh filter is applied to the adsorbent particles, removing microparticles in advance. This preliminary action ensures that when the adsorber is used clinically, microparticles cannot enter the patient's body, while still allowing the use of general-purpose carriers
Solution Approach 2:
The mesh filter acts as an intermediary between the adsorbent and the patient's body. The mesh with opening size of 1.3-1.5 times the adsorber mesh opening size physically blocks microparticles from entering the patient's circulation while allowing normal blood flow through the adsorber. This intermediary structure provides a simple yet effective safety mechanism
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables the production of direct hemoperfusion adsorbers with water-insoluble microparticles removed to a therapeutically safe level, simplifying the production process and enhancing safety without the need for special equipment or coatings, thereby reducing costs and improving operational ease.
Implementation Method 1
removing water-insoluble microparticles from an adsorbent... by using a mesh such that the ratio of the mesh opening size for removing water-insoluble microparticles to the mesh opening size of the adsorber is not lower than 1.3 but not higher than 1.5
Data Source
AI summary
The present invention has its object to provide a direct hemoperfusion adsorber packed with an adsorbent made by using a water-insoluble carrier having a relatively readily available particle size distribution, with water-insoluble microparticles having been removed therefrom, without needing any special granulation apparatus or coating apparatus, and method of obtaining a direct hemoperfusion adsorbent having water-insoluble microparticles removed therefrom.Now, a direct hemoperfusion adsorber has been obtained that is packed with an adsorbent having a number average particle diameter of not smaller than 300 μm but not larger than 600 μm, with the coefficient of variance in particle diameter distribution being not lower than 10% but not higher than 20%, and having water-insoluble microparticles removed therefrom to a safe level, without the loss of the adsorbent, by using a water-insoluble microparticle-removing-mesh such that the ratio of the mesh opening size for removing water-insoluble microparticles to the mesh opening size of the adsorber is not lower than 1.3 but not higher than 1.5.