Hemostatic Cellulose Dressing with Controlled Decomposition
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Solution Overview
Problem
Current wound dressings either fail to absorb wound secretions effectively, leading to adherence issues and pain, or lack hemostatic properties, limiting their use in wet environments and surgical applications.
Innovation Solution
A method involving pretreatment of natural cellulose substrates to enhance hemostatic agent adsorption, followed by modification with monochloroacetic acid and organic acids like citric and ascorbic acid to control decomposition rates, ensuring effective hemostasis and absorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If cotton dressing is used for wound absorption, then moisture absorption is improved, but the dressing adheres to the wound surface causing pain and difficulty in changing
Solution Approach 1:
The patent modifies the cellulose substrate through chemical treatment with monochloroacetic acid and organic acids to change the surface properties and decomposition characteristics. This parameter change allows the dressing to maintain absorption capacity while preventing harmful adherence to the wound surface.
Solution Approach 2:
The patent creates a composite structure by combining cellulose substrate with hemostatic agents and modifying it through chemical treatment. This composite approach enables the material to simultaneously provide absorption, hemostasis, and controlled decomposition without adhering to the wound surface.
2Reliability
If transparent film dressing is used to block infection, then infection protection is improved, but absorption power is lost limiting use in wet environments
Solution Approach 1:
The patent develops a universal dressing material that combines the infection protection capability of transparent films with the absorption power of cellulose-based materials. The modified cellulose substrate provides both functions, enabling use in wet environments while maintaining infection barrier properties.
3Reliability
If hemostatic components are added to dressing materials for immediate hemostatic action, then hemostasis is improved, but surgery is interfered with
Solution Approach 1:
The patent introduces controlled decomposition capability to the hemostatic dressing material. The material can dynamically adjust its hemostatic activity through controlled decomposition, allowing immediate hemostasis when needed while enabling removal or reduced activity during surgical procedures, thus adapting to different clinical scenarios.
Solution Approach 2:
The patent modifies the decomposition rate of the cellulose substrate through chemical treatment with monochloroacetic acid and organic acids. This parameter change allows control over the timing and rate of hemostatic agent release, enabling immediate hemostasis when required while preventing interference with surgical operations.
4Reliability
If natural cellulose substrate is used for medical material, then biosafety is improved, but decomposition rate is uncontrolled
Solution Approach 1:
The patent systematically modifies the decomposition rate parameter of natural cellulose through controlled chemical treatment with monochloroacetic acid and organic acids. This allows precise control over the decomposition timing while preserving the biosafety advantages of natural cellulose.
Solution Approach 2:
The patent uses monochloroacetic acid and organic acids as intermediary substances to mediate the modification of cellulose substrate. These intermediaries enable controlled decomposition rate adjustment without compromising the biosafety properties of the natural cellulose base material.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method achieves controlled hemostasis and decomposition, enhancing wound treatment efficiency by maintaining biosafety and flexibility in application, from urgent to sustained hemostatic effects.
Implementation Method 1
a hemostatic agent is adsorbed on a natural cellulose substrate
Implementation Method 2
the decomposition rate is controlled after being modified with a monochloroacetic acid (MCA) and an organic acid
Data Source
AI summary
Proposed are a method of manufacturing a hemostatic medical material that has excellent biosafety and can be applied to various situations by controlling the decomposition rate as necessary, and a medical material manufactured thereby. The method includes pretreating a natural cellulose substrate by adjusting the pH of the substrate, causing the hemostatic agent to be adsorbed on the pretreated substrate, drying the substrate with the hemostatic agent adsorbed thereon, primarily modifying the dried substrate using monochloroacetic acid (MCA), secondarily modifying the primarily modified substrate using an organic acid aqueous solution, washing the secondarily modified substrate, and post treating the substrate by adjusting the pH of the washed substrate.