Multilayered Hemostatic Device for Powder Delivery
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Solution Overview
Problem
Current powdered hemostatic agents are difficult to handle and apply precisely, often leading to waste due to imprecise delivery and blowing away from the wound site.
Innovation Solution
A multilayered hemostatic device with a soluble first layer, a powdered hemostatic agent second layer, and a third layer (which may be soluble or non-degradable) that encapsulates the second layer, allowing for precise and controlled application and maximizing the use of the hemostatic agent at the wound site.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If powdered hemostatic agents are applied using plastic bellow type applicators, then the hemostatic agent can be delivered to the wound site, but the agent is blown away from the wound site resulting in significant waste
Solution Approach 1:
The hemostatic agent is segmented into a multi-layered structure with distinct functional layers: a first layer containing the powdered hemostatic agent, a second layer as a barrier, and a third layer as a release layer. This segmentation prevents the agent from being blown away while allowing controlled release at the wound site.
Solution Approach 2:
The hemostatic agent is pre-positioned within the multi-layered device structure before application. The first layer is prepared with the agent, sealed between layers, and ready for controlled release, eliminating the need for manual handling and application that causes waste.
2Manufacturing precision
If a multilayered structure with soluble first layer and third layer is used to encapsulate the powdered hemostatic agent, then precise and controlled application is achieved, but the device complexity increases
Solution Approach 1:
The device utilizes parameter changes in the form of dissolution rates. The first layer is made soluble to dissolve rapidly upon contact with wound fluid, while the third layer is made of oxidized cellulose that degrades more slowly. This parameter differentiation enables controlled release without requiring complex active control mechanisms.
Solution Approach 2:
The device employs composite materials with different properties in each layer. The first layer uses a soluble material for rapid release, the second layer provides a barrier function, and the third layer uses oxidized cellulose for sustained structure. This composite approach achieves precision through material selection rather than mechanical complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device ensures precise delivery and application of powdered hemostatic agents, minimizing waste and ensuring maximum utilization at the surgical site.
Implementation Method 1
the first layer being soluble under physiological conditions, such that the first layer will dissolve when in contact with a fluid from a wound
Implementation Method 2
the third layer comprising at least one of gauze, oxidized cellulose, or collagen provided on the second layer
Data Source
Figure 1
Figure 2
AI summary
The disclosure provides a multilayered hemostatic device including a first layer including carboxymethyl cellulose, a second layer including a powdered hemostatic agent provided on the first layer, and a third layer including at least one of gauze, oxidized cellulose, or collagen provided on the second layer, wherein the first layer and the third layer encapsulate the second layer and the hemostatic agent comprises one of fibrinogen, thrombin, fibrin monomers, or the combination of thrombin and gelatin.