Multilayered Hemostatic Dressing Shielding Thrombin
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Solution Overview
Problem
Carboxylic-oxidized cellulose can denature the activity of thrombin and fibrinogen when used together, compromising their hemostatic properties in wound dressings.
Innovation Solution
A reinforced absorbable multilayered hemostatic wound dressing is developed, comprising a nonwoven fabric made of aliphatic polyester polymers and a reinforcement fabric of oxidized regenerated cellulose, where thrombin and/or fibrinogen are dispersed throughout the nonwoven fabric to shield them from acidic moieties and provide strength.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If carboxylic-oxidized cellulose is used in combination with thrombin and/or fibrinogen, then the dressing provides bactericidal, tissue sealing and hemostatic properties, but the acidic moieties in the cellulose denature the activity of thrombin and/or fibrinogen
Solution Approach 1:
The dressing is divided into multiple functional layers: a first layer containing thrombin and/or fibrinogen embedded in an inert carrier, and a second layer containing carboxylic-oxidized cellulose. This segmentation physically separates the hemostatic agents from the acidic moieties, preventing denaturation while maintaining both bactericidal and hemostatic functions.
Solution Approach 2:
An inert carrier material serves as an intermediary between the thrombin/fibrinogen and the carboxylic-oxidized cellulose. This intermediate layer protects the sensitive hemostatic agents from direct contact with acidic moieties while still allowing the dressing to provide comprehensive wound management functionality.
2Reliability
If a multilayered structure is created to shield thrombin from acidic moieties, then hemostatic activity is maintained, but the device complexity increases
Solution Approach 1:
The dressing consists of two distinct layers with specific functions: the first layer provides hemostasis protection while the second layer provides bactericidal and tissue sealing properties. This segmentation achieves the protective function with minimal structural complexity.
Solution Approach 2:
Each layer is designed to perform multiple functions: the first layer with inert carrier provides both physical protection and drug delivery, while the second layer with oxidized cellulose provides bactericidal action, tissue sealing, and structural support. This multi-functionality reduces the need for additional protective components.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The dressing effectively maintains hemostasis in severe bleeding cases by controlling bleeding and sealing tissues, while the nonwoven fabric shields thrombin and fibrinogen from acidic moieties, ensuring their activity and providing sufficient strength for wound management.
Implementation Method 1
the first absorbable nonwoven fabric comprises fibers comprising aliphatic polyester polymers, copolymers, or blends thereof, while the second absorbable woven or knitted fabric comprises oxidized regenerated cellulose fibers
Implementation Method 2
the second absorbable woven or knitted fabric comprises oxidized regenerated cellulose fibers
Data Source
AI summary
The present invention is directed to a reinforced absorbable multilayered hemostatic wound dressing comprising a first absorbable nonwoven fabric, a second absorbable woven or knitted fabric, thrombin and/or fibrinogen.