Multilayered Hemostatic Dressing Shielding Thrombin

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Solution Overview

Problem

Carboxylic-oxidized cellulose can denature the activity of thrombin and fibrinogen when used together, compromising their hemostatic properties in wound dressings.

Innovation Solution

A reinforced absorbable multilayered hemostatic wound dressing is developed, comprising a nonwoven fabric made of aliphatic polyester polymers and a reinforcement fabric of oxidized regenerated cellulose, where thrombin and/or fibrinogen are dispersed throughout or on the surface of the nonwoven fabric to shield them from acidic moieties and provide strength.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If carboxylic-oxidized cellulose is combined with thrombin and/or fibrinogen in wound dressing, then the dressing provides bactericidal, tissue sealing and hemostatic properties, but the acidic moieties in the cellulose denature the activity of thrombin and/or fibrinogen

Engineering Contradiction:

Improvehemostatic activityVSAvoidacidic moiety denaturation

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The wound dressing is divided into multiple functional layers: a first layer containing thrombin and/or fibrinogen, and a second layer containing carboxylic-oxidized cellulose. This segmentation physically separates the hemostatic agents from the acidic cellulose, preventing denaturation while maintaining all desired properties.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

A barrier layer or coating is introduced between the thrombin/fibrinogen-containing layer and the carboxylic-oxidized cellulose layer. This intermediary protects the hemostatic agents from direct contact with acidic moieties while allowing the dressing to maintain its bactericidal, tissue sealing and hemostatic functions.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If carboxylic-oxidized cellulose is used in wound dressing, then the dressing provides tissue sealing and adhering properties, but the acidic moieties compromise the stability of thrombin and/or fibrinogen

Engineering Contradiction:

Improvetissue sealing propertyVSAvoidthrombin/fibrinogen stability

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The dressing is segmented into distinct layers where tissue sealing agents (carboxylic-oxidized cellulose) are separated from stability-sensitive components (thrombin and/or fibrinogen). This ensures tissue sealing effectiveness while protecting the stability of hemostatic agents.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

A protective barrier is placed between the acidic cellulose layer and the thrombin/fibrinogen layer, acting as an intermediary that allows tissue sealing functionality while preventing chemical degradation of the hemostatic agents.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Strength

If a single-layer dressing is used, then the manufacturing process is simple, but the dressing cannot provide both strength and protection from acidic moieties simultaneously

Engineering Contradiction:

Improvedressing strengthVSAvoidmultilayered structure

Core Design Contradiction:

StrengthVSDevice complexity

Solution Approach 1:

The dressing is segmented into multiple layers, each optimized for specific functions: one layer provides structural strength, another layer contains protected hemostatic agents, and another provides tissue sealing. This segmentation allows simultaneous achievement of strength and chemical protection.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The wound dressing is constructed as a composite material system combining different materials with complementary properties: a strength-providing layer, a hemostatic agent-containing layer, and a carboxylic-oxidized cellulose layer. This composite structure achieves multiple functions that cannot be obtained with a single material.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The dressing effectively maintains hemostasis in severe bleeding cases by controlling bleeding and sealing tissues, while the nonwoven fabric shields thrombin and fibrinogen from acidic moieties, ensuring their hemostatic activity and providing sufficient strength for wound management.

Implementation Method 1

the nonwoven fabric shields thrombin and/or fibrinogen from acidic moieties that may be present in the reinforcement fabric

Methodology Applied

Scientific EffectPhysical barrier protection: Physical Containment

Implementation Method 2

a first absorbable nonwoven fabric reinforced by one or more second absorbable woven or knitted fabric

Methodology Applied

Scientific EffectFiber reinforcement: Composite Materials

Implementation Method 3

The first absorbable nonwoven fabric comprises fibers comprising aliphatic polyester polymers, copolymers, or blends thereof

Methodology Applied

Scientific EffectBiodegradation: Decomposition (biological)

Data Source

PatentUS9439997B2Reinforced absorbable multilayered hemostatis wound dressing

Publication Date: 2016.09.13 OMRIX BIOPHARMACEUTICALS SA

AI summary

The present invention is directed to a reinforced absorbable multilayered hemostatic wound dressing comprising a first absorbable nonwoven fabric, a second absorbable woven or knitted fabric, thrombin and/or fibrinogen.