Hemostatic Composition Using Hydrophobic Solvent for Stability
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Solution Overview
Problem
Existing hemostatic materials, such as thrombin-containing gelatin pastes, face challenges in storage stability due to the decomposition of N-hydroxysuccinimide ester groups when exposed to water, which can compromise their effectiveness in controlling bleeding.
Innovation Solution
A hemostatic material composition incorporating a polysaccharide with reactive groups, crosslinked particles, and a hydrophobic solvent, where the polysaccharide reacts with proteins to form crosslinking structures, and the crosslinked particles absorb water, enhancing storage stability and hemostatic properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If a hydrophilic solvent is used in the hemostatic material composition, then the hemostatic material can be properly formulated and applied, but the N-hydroxysuccinimide ester group reacts with water and decomposes, resulting in temporal deterioration of hemostatic properties
Solution Approach 1:
The patent removes water from the solvent system entirely, extracting the harmful element (water) that causes decomposition of the N-hydroxysuccinimide ester group. The composition uses an anhydrous organic solvent instead of a hydrophilic solvent, eliminating the water-reactive pathway while maintaining formulability through alternative solvent selection.
Solution Approach 2:
The patent changes the fundamental parameter of solvent water content from containing water (hydrophilic) to being completely anhydrous. This parameter change transforms the chemical environment from one where hydrolysis occurs to one where the N-hydroxysuccinimide ester group remains stable, thereby resolving the contradiction between formulability and storage stability.
2Ease of operation
If water is present in the hemostatic material composition, then the material can maintain flexibility and workability, but the reactive group decomposes due to reaction with water, compromising long-term stability
Solution Approach 1:
The patent introduces an anhydrous organic solvent as an intermediary substance that mediates between the need for material workability and the requirement for chemical stability. This intermediary solvent provides the necessary fluidity and workability without containing water, thus preventing decomposition of the N-hydroxysuccinimide ester group while maintaining operational ease.
3Reliability
If the N-hydroxysuccinimide ester group is used for crosslinking, then excellent hemostatic properties are achieved, but the group reacts with trace water and decomposes over time, reducing effectiveness
Solution Approach 1:
The patent applies preliminary anti-action by preventing water from being present in the composition before the N-hydroxysuccinimide ester group can decompose. By formulating the product in an anhydrous environment from the outset, the patent preemptively blocks the hydrolysis reaction pathway, thereby preserving both the hemostatic effectiveness and extending the shelf life of the material.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition exhibits improved storage stability and hemostatic performance by preventing decomposition of reactive groups and maintaining effectiveness over time, even when exposed to trace amounts of water.
Implementation Method 1
a polysaccharide having a reactive group that reacts with a protein to form a crosslinking structure
Implementation Method 2
a hemostatic material composition incorporating a polysaccharide with reactive groups, crosslinked particles, and a hydrophobic solvent
Implementation Method 3
the crosslinked particles absorb water, enhancing storage stability and hemostatic properties
Data Source
AI summary
The hemostatic material composition contains a polysaccharide having a reactive group that reacts with a protein to form a crosslinking structure, a hydrophobic solvent, and a crosslinked particle containing one or more compounds selected from the group consisting of a crosslinked protein and a crosslinked polysaccharide.