Bioabsorbable Scaffold for Hemostatic Powder Adherence
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Solution Overview
Problem
Current hemostatic products face challenges in effectively delivering lyophilized hemostasis-promoting proteins like fibrinogen and thrombin to wounds, particularly in maintaining their potency and adherence to the wound site, which can be compromised by premature activation or inadequate moisture exposure.
Innovation Solution
A bioabsorbable scaffold is wetted with a biocompatible liquid, allowing a hemostatic powder mixture of dry fibrinogen and thrombin to adhere to its surface, which is then applied to the wound, utilizing capillary forces to maintain the powders in place until application, ensuring rapid hydration and effective clot formation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If lyophilized hemostasis-promoting proteins are delivered to wounds using conventional methods, then hemostatic activity is achieved, but adherence to the wound site is compromised due to premature activation or inadequate moisture exposure
Solution Approach 1:
The scaffold is pre-wetted with biocompatible liquid before application to the wound site. This preliminary moistening ensures that the lyophilized hemostasis-promoting proteins adhere properly to the scaffold surface upon contact, preventing premature activation while ensuring adequate moisture exposure for effective clot formation at the wound site
Solution Approach 2:
A biocompatible liquid serves as an intermediary medium between the lyophilized proteins and the wound site. This liquid facilitates proper adherence of the proteins to the scaffold while controlling the hydration process, ensuring that activation occurs only when needed at the wound site rather than during handling or storage
2Ease of operation
If the scaffold is wetted with biocompatible liquid before application, then powder adherence is improved, but there is risk of premature protein activation
Solution Approach 1:
The scaffold is pre-wetted with biocompatible liquid before application to the wound site. This preliminary moistening ensures that the lyophilized hemostasis-promoting proteins adhere properly to the scaffold surface upon contact, preventing premature activation while ensuring adequate moisture exposure for effective clot formation at the wound site
Solution Approach 2:
The physical state of the scaffold surface is changed from dry to moist through controlled wetting with biocompatible liquid. This parameter change enables powder adherence through capillary forces while the controlled nature of the wetting process prevents premature protein activation by ensuring uniform moisture distribution only when needed
3Stability of the object's composition
If lyophilized proteins are stored as dry powder, then stability is maintained, but effectiveness is reduced without adequate moisture exposure
Solution Approach 1:
The system is segmented into two distinct components: dry lyophilized proteins for stable storage and a biocompatible liquid for controlled hydration. This segmentation allows the proteins to maintain stability during storage as dry powder while ensuring effectiveness is achieved only when the liquid is applied at the wound site, triggering controlled activation
Solution Approach 2:
The physical state of the proteins is changed from dry to hydrated through controlled application of biocompatible liquid. This parameter change enables the proteins to transition from a stable storage state to an effective therapeutic state only when needed at the wound site, ensuring both stability during storage and effectiveness during application
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method ensures rapid and effective hemostasis with excellent adherence to the wound tissue, maintaining the hemostatic and adhesive properties of the fibrinogen and thrombin, even when applied shortly after assembly, thereby effectively controlling bleeding and promoting tissue sealing.
Implementation Method 1
utilizing capillary forces to maintain the powders in place until application
Implementation Method 2
ensuring rapid hydration and effective clot formation
Implementation Method 3
When bleeding occurs, the fibrinogen reacts with water and thrombin (an enzyme) to form fibrin, which is insoluble in blood and polymerizes to form clots
Data Source
AI summary
The present invention relates generally to agents and devices for promoting hemostasis and tissue sealing and, more particularly, to hemostatic pads comprising bioabsorbable scaffolds that can deliver lyophilized hemostasis promoting proteins, such as fibrinogen and thrombin, to a wound site or injured organ or tissue.