Cross-Linked Hemostatic Sponge With Low-Swelling Tissue Adhesion

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Existing collagen-based hemostatic pads fail to induce hemostasis effectively under impaired conditions, such as heparinization, and surface materials tend to detach during application, while hydrogel components increase swelling.

Innovation Solution

A hemostatic porous composite sponge with a biomaterial matrix and a surface-enhancing material, free of hydrogel components, is stabilized through cross-linkable components that adhere covalently to tissue, ensuring stability and flexibility.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If hydrogel components are added to enhance hemostatic action, then hemostatic effectiveness is improved, but swelling increases

Engineering Contradiction:

Improvehemostatic effectivenessVSAvoidswelling

Core Design Contradiction:

ReliabilityVSVolume of moving object

Solution Approach 1:

The patent removes hydrogel components from the hemostatic sponge composition while retaining the biomaterial matrix (collagen, gelatin, or fibrin). This extraction eliminates the excessive swelling problem associated with hydrogels while preserving the essential hemostatic functionality through the biomaterial's inherent properties and incorporated hemostatic agents.

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The invention creates a composite material consisting of a biomaterial matrix combined with hemostatic agents (thrombin, fibrinogen, factor XIII, or proactivators) without hydrogel components. This composite structure achieves effective hemostasis through the synergistic interaction of the biomaterial and hemostatic agents while avoiding the swelling issues of hydrogel-based systems.

Inventive Principle:

Principle #40Composite materials

2Reliability

If surface materials are applied to enhance adherence to tissue, then hemostatic action is improved, but materials detach during application

Engineering Contradiction:

Improvehemostatic actionVSAvoidadherence stability

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent merges the surface-enhancing material with the bulk sponge matrix through homogeneous distribution of hemostatic agents throughout the biomaterial matrix. This integration ensures that the entire sponge, including the surface, maintains stable adherence properties without detachment during application, while still providing effective hemostatic action.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention applies local quality by incorporating hemostatic agents and surface-enhancing properties directly into the biomaterial matrix at the molecular level. This creates uniform local properties throughout the sponge that ensure stable tissue adherence at the application site while maintaining overall structural integrity.

Inventive Principle:

Principle #3Local quality

3Reliability

If collagen pads are used for hemostasis, then wound healing is improved, but hemostasis fails under impaired conditions such as heparinization

Engineering Contradiction:

Improvewound healingVSAvoideffectiveness under impaired conditions

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent creates a multi-functional hemostatic sponge that combines the wound healing properties of collagen-based biomaterials with additional hemostatic mechanisms (thrombin activation, fibrin formation, factor XIII cross-linking). This universal composition enables the sponge to effectively induce hemostasis under various conditions including heparinization, while simultaneously promoting wound healing.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The invention develops a composite hemostatic material that integrates collagen-based biomaterial with multiple hemostatic agents. This composite structure provides both the tissue compatibility and wound healing promotion of collagen while adding robust hemostatic capability that functions even when the coagulation system is impaired by heparin or other anticoagulants.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The sponge effectively induces hemostasis even under impaired conditions and maintains adherence to tissue geometry, with reduced swelling and enhanced stability.

Implementation Method 1

cross-linkable components that adhere covalently to tissue

Methodology Applied

Scientific EffectCovalent bonding: Chemical Bonding

Implementation Method 2

hydrogel components increase swelling

Methodology Applied

Scientific EffectAbsorption: Absorption (physical)

Data Source

PatentUS20250367338A1Hemostatic sponge

Publication Date: 2025.12.04 BAXTER INT INC

AI summary

The present invention provides a hemostatic composite sponge comprising oxidized cellulose and an essentially gelatin-free bioadhesive material stably associated with said sponge and present in an organized pattern on said sponge.