Solid Hemostatic Tablet for Uniform Wound Pressure

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Solution Overview

Problem

Existing hemostatic products, such as powders and granulations, face challenges in delivering effective hemostasis due to messiness and uneven application, leading to slower action and reduced efficacy compared to solid forms, which are denser and have a reduced surface area.

Innovation Solution

A solid hemostatic tablet formed by compressing a mixture of insoluble cation exchange material and anhydrous salt ferrate, with a specific particle size range and composition, is applied to wounds with pressure to create a uniform seal and reservoir for sustained hemostasis and antimicrobial protection.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Speed

If loose hemostatic powder is used, then the surface area in contact with the wound is larger, but the application is messy and the action is slower

Engineering Contradiction:
Improvespeed of hemostasisVSAvoidease of application
Core Design Contradiction:
SpeedVSEase of operation

Solution Approach 1:

The hemostatic material is segmented into a solid tablet form that can be easily applied and controlled, while still providing effective hemostasis through its compressed structure

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The physical state of the hemostatic material is changed from loose powder to compressed solid tablet, altering its density, surface area, and application characteristics while maintaining hemostatic efficacy

Inventive Principle:
Principle #35Parameter changes

2Ease of operation

If hemostatic powder is compressed into a solid tablet, then the application is less messy, but the surface area is reduced

Engineering Contradiction:
Improveease of applicationVSAvoidsurface area
Core Design Contradiction:
Ease of operationVSArea of stationary object

Solution Approach 1:

The compression process changes the physical parameters of the hemostatic material, creating a solid tablet with controlled density and surface area that balances ease of application with effective wound contact

Inventive Principle:
Principle #35Parameter changes

3Stability of the object's composition

If high compressive force is applied to form a dense tablet, then the tablet is less messy, but the surface area is reduced

Engineering Contradiction:
ImprovedensityVSAvoidsurface area
Core Design Contradiction:
Stability of the object's compositionVSArea of stationary object

Solution Approach 1:

High compressive force is applied to transform the hemostatic powder into a dense solid tablet, changing its physical state to improve stability and reduce messiness while controlling the resulting surface area

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solid tablet adheres more tenaciously to wounds, achieving hemostasis faster and providing long-term protection against bleeding and infection, contrary to expectations, as it applies uniform pressure and maintains a larger surface area in contact with the wound compared to loose powders.

Implementation Method 1

a solid hemostatic tablet formed by compression of a powder of an insoluble cation exchange material and an anhydrous salt ferrate

Methodology Applied
Scientific EffectCompression: Compression

Implementation Method 2

a portion of at least 40% of said beads being fractured

Methodology Applied
Scientific EffectAdsorption: Adsorption

Implementation Method 3

anhydrous salt ferrate

Methodology Applied
Scientific EffectOxidation: Oxidation

Data Source

PatentEP2976090B1Hemostatic device and method
Publication Date: 2019.03.13 BIOLIFE LLC
  • EP2976090B1 patent drawingFigure 1~6A
  • EP2976090B1 patent drawingFigure 7~8
  • EP2976090B1 patent drawingFigure 9~10

AI summary

A hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery to a bleeding wound. The tablet improves the rate of adhesion to a bleeding wound surface, and allows a significantly greater and more uniform pressure to be exerted by manual compression of the tablet on the wound site, as compared to that of a thin layer of scattered hemostatic powder. After the seal is formed from the interaction of blood or exudates with the immediate contacting surface of the tablet, the bulk of the unused tablet easily delaminates from the seal making clean up facile. If the unused portion of the tablet is not removed from the wound site, a reservoir of hemostatic dressing stops further bleeding and to provide antimicrobial protection and healing. The tablet may be applied to any surface orientation and take any shape and thickness possible.